Peptide‐based covalent inhibitors of protein–protein interactions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3457
Abstract: Protein–protein interactions (PPI) are involved in all cellular processes and many represent attractive therapeutic targets. However, the frequently rather flat and large interaction areas render the identification of small molecular PPI inhibitors very challenging. As… read more here.
Keywords: peptide based; inhibitors protein; protein protein; based covalent ... See more keywords
Selected flavonoid compounds as promising inhibitors of protein kinase CK2α and CK2α', the catalytic subunits of CK2.
Sign Up to like & getrecommendations! Published in 2017 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2016.12.018
Abstract: CK2 is a ubiquitous protein kinase involved in many cell functions. During the last years it became an interesting target in cancer research. A series of flavonoid compounds was tested as inhibitors of protein kinase… read more here.
Keywords: catalytic subunits; flavonoid compounds; kinase ck2; protein kinase ... See more keywords
Inhibitors of Protein Methyltransferases and Demethylases
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DOI: 10.1021/acs.chemrev.6b00801
Abstract: Post-translational modifications of histones by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regulation of gene expression and transcription and are implicated in cancer and many other diseases. Many of… read more here.
Keywords: inhibitors protein; methyltransferases demethylases; protein methyltransferases;
Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12748
Abstract: Electrophilic cofactors are widely distributed in nature and play important roles in many physiological and disease processes, yet they have remained blind spots in traditional activity-based protein profiling (ABPP) approaches that target nucleophiles. More recently,… read more here.
Keywords: inhibitors protein; electrophilic cofactors; discovery potent; glox ... See more keywords
High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria
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DOI: 10.1128/aac.00237-22
Abstract: Artemisinin-based combination therapies have been crucial in driving down the global burden of malaria, the world’s largest parasitic killer. However, their efficacy is now threatened by the emergence of resistance in Southeast Asia and sub-Saharan… read more here.
Keywords: inhibitors protein; platform; screening platform; throughput screening ... See more keywords