Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.
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DOI: 10.1021/acsmedchemlett.4c00183
Abstract: Substituted imidazolidinetriones (IZTs) have been identified as potent inhibitors of pyruvate carboxylase (PC) through an in silico screening approach. Alkyl 2-(2,4,5-trioxo-3-substituted imidazolidin-1-yl)acetates (6i-6r) are the most potent of the series, with IC50 values between 3… read more here.
Keywords: imidazolidine triones; pyruvate carboxylase; inhibitors pyruvate; synthesis evaluation ... See more keywords