Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone.
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DOI: 10.1016/j.drudis.2020.07.015
Abstract: Catechol O-methyltransferase (COMT) inhibitors are valuable co-adjuvant drugs in the clinical management of Parkinson's disease (PD), and recent data also suggest therapeutic benefits in other neurological disorders associated with dopamine depletion. However, the relationship between… read more here.
Keywords: catechol methyltransferase; replace tolcapone; comt inhibitors; inhibitors replace ... See more keywords