BRAF inhibitors: resistance and the promise of combination treatments for melanoma
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DOI: 10.18632/oncotarget.19836
Abstract: Identification of mutations in the gene encoding the serine/threonine-protein kinase, BRAF, and constitutive activation of the mitogen-activated protein kinase (MAPK) pathway in around 50% of malignant melanomas have led to the development and regulatory approval… read more here.
Keywords: inhibitors resistance; combination; resistance promise; combination treatments ... See more keywords
PARP Inhibitors Resistance: Mechanisms and Perspectives
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DOI: 10.3390/cancers14061420
Abstract: Simple Summary This review aims to analyze the emerging issue regarding PARP inhibitor’s resistance in tumors and their consequence on disease prognosis and treatment. Besides, we evaluate possible strategies and new therapeutic approaches to overcome… read more here.
Keywords: resistance; resistance mechanisms; inhibitors resistance; parpis ... See more keywords