Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate
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DOI: 10.1002/cbic.201700547
Abstract: We describe the design, synthesis, and structure–activity relationships (SARs) of a series of 2‐aminobenzothiazole inhibitors of Rho kinases (ROCKs) 1 and 2, which were optimized to low nanomolar potencies by use of protein kinase A (PKA)… read more here.
Keywords: rho kinases; protein kinase; aminobenzothiazole inhibitors; inhibitors rho ... See more keywords