Acid sphingomyelinase (ASM) and COVID‐19: A review of the potential use of ASM inhibitors against SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3789
Abstract: In the last 2 years, different pharmacological agents have been indicated as potential inhibitors of SARS‐CoV‐2 in vitro. Specifically, drugs termed as functional inhibitors of acid sphingomyelinase (FIASMAs) have proved to inhibit the SARS‐CoV‐2 replication… read more here.
Keywords: inhibitors sars; review; asm; sphingomyelinase asm ... See more keywords
A Critical Study on Acylating and Covalent Reversible Fragment Inhibitors of SARS‐CoV‐2 Main Protease Targeting the S1 Site with Pyridine
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200635
Abstract: SARS coronavirus main proteases (3CL proteases) have been validated as pharmacological targets for the treatment of coronavirus infections. Current inhibitors of SARS main protease, including the clinically admitted drug nirmatrelvir are peptidomimetics with the downsides… read more here.
Keywords: inhibitors sars; main protease; covalent; site ... See more keywords
Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2: A Combined in silico and in vitro Study.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular informatics"
DOI: 10.1002/minf.202100062
Abstract: In the current study, we used 7922 FDA approved small molecule drugs as well as compounds in clinical investigation from NIH's NPC database in our drug repurposing study. SARS-CoV-2 main protease as well as Spike… read more here.
Keywords: inhibitors sars; study; investigation; main protease ... See more keywords
Identification of natural compounds as potent inhibitors of SARS-CoV-2 main protease using combined docking and molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.01.040
Abstract: Coronavirus disease 2019 (COVID-19) has emerged from China and globally affected the entire population through the human-to-human transmission of a newly emerged virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The genome of SARS-CoV-2… read more here.
Keywords: natural compounds; molecular dynamics; inhibitors sars; cov mpro ... See more keywords
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.0c00502
Abstract: Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of “coronavirus disease 2019”, abbreviated to COVID-19, which despite… read more here.
Keywords: current future; entry current; inhibitors sars; cov entry ... See more keywords
Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "ACS Nano"
DOI: 10.1021/acsnano.0c02857
Abstract: Peptide inhibitors against the SARS-CoV-2 coronavirus, currently causing a worldwide pandemic, are designed and simulated. The inhibitors are mostly formed by two sequential self-supporting α-helices (bundle) extracted from the protease domain (PD) of angiotensin-converting enzyme… read more here.
Keywords: computational design; design ace2; inhibitors sars; sars cov ... See more keywords
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra06212j
Abstract: Originating for the first time in Wuhan, China, the outbreak of SARS-CoV-2 has caused a serious global health issue. An effective treatment for SARS-CoV-2 is still unavailable. Therefore, in this study, we have tried to… read more here.
Keywords: inhibitors sars; cov main; main protease; sars cov ... See more keywords
Dietary stigmastane-type saponins as promising dual-target directed inhibitors of SARS-CoV-2 proteases: a structure-based screening
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra05976a
Abstract: Vernonia amygdalina derived phytochemicals as potential dual-target directed inhibitors of SARS-CoV-2 proteases from computational study perspective. read more here.
Keywords: dual target; target directed; inhibitors sars; cov proteases ... See more keywords
Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20201256
Abstract: Abstract Due to the lack of efficient therapeutic options and clinical trial limitations, the FDA-approved drugs can be a good choice to handle Coronavirus disease (COVID-19). Many reports have enough evidence for the use of… read more here.
Keywords: inhibitors sars; fda approved; main protease; glecaprevir maraviroc ... See more keywords
In silico and in vitro studies on inhibitors for SARS-CoV-2 non-structural proteins with dual herbal combination of Withania somnifera with five rasayana herbs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2046642
Abstract: Abstract Being highly transmissible, severe acute respiratory syndrome coronavirus (SARS-CoV-2) has affected millions of people causing devastating global impact and has also not slowed down even after vaccination. The emerges of new strains has made… read more here.
Keywords: studies inhibitors; vitro studies; inhibitors sars; silico vitro ... See more keywords
Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13366
Abstract: Since late 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral outbreak has spread all over the world. The disease caused by SARS-CoV-2, named COVID-19, has caused over 550,000 deaths and infected close to… read more here.
Keywords: dehydrogenase inhibitors; inhibitors sars; sars cov; cov infection ... See more keywords