Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity
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DOI: 10.3390/ph15111340
Abstract: New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target. We herein report the synthesis and biological… read more here.
Keywords: synthesis biological; thrombin inhibitors; biological activity; inhibitors serine ... See more keywords