Quinoline containing chalcone derivatives as cholinesterase inhibitors and their in silico modeling studies
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.08.003
Abstract: Cholinesterases (ChEs) play a vital role in regulating cholinergic transmission. Inhibition of ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative disorders through restoration of acetylcholine (ACh) levels in the brain… read more here.
Keywords: quinoline containing; containing chalcone; chalcone derivatives; inhibitors silico ... See more keywords
Discovery of GSK3β Inhibitors through In Silico Prediction-and-Experiment Cycling Strategy, and Biological Evaluation
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DOI: 10.3390/molecules27123825
Abstract: Direct inhibitors of glycogen synthase kinase 3β (GSK3β) have been investigated and reported for the past 20 years. In the search for novel scaffold inhibitors, 3000 compounds were selected through structure-based virtual screening (SBVS), and… read more here.
Keywords: gsk3 inhibitors; silico prediction; inhibitors silico; gsk3 ... See more keywords