Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
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DOI: 10.1016/j.bioorg.2019.103281
Abstract: Sirtuins (SIRTs), class III HDAC (Histone deacetylase) family proteins, are associated with cancer, diabetes, and other age-related disorders. SIRT1 and SIRT2 are established therapeutic drug targets by regulating its function either by activators or inhibitors.… read more here.
Keywords: sirt1 sirt2; design synthesis; sirt2; inhibitors sirt1 ... See more keywords