Allosteric inhibitors of the STAT3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112122
Abstract: Over-expression and/or hyperactivation of signal transducer and activator of transcription 3 (STAT3) signaling are found in various human diseases, including cancer, autoimmune disorders, and inflammatory diseases. Therefore, STAT3 represents a highly promising therapeutic target for… read more here.
Keywords: inhibitors stat3; allosteric inhibitors; chemistry; signaling pathway ... See more keywords
Synthesis of thienopyrimidine derivatives as inhibitors of STAT3 activation induced by IL-6.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1811.11046
Abstract: A series of thienopyrimidine compounds (6Aa-g and 6Ba-d) were synthesized and characterized by NMR spectroscopy and mass spectrometry. These compounds (6Aa-g and 6Ba-d) potently inhibited STAT3 expression induced by IL-6 in a dose-dependent manner with… read more here.
Keywords: thienopyrimidine; synthesis thienopyrimidine; derivatives inhibitors; inhibitors stat3 ... See more keywords