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Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201600536
Abstract: A total of 48 analogues of the natural product myxochelin A were prepared and evaluated for their inhibitory effects on human 5‐lipoxygenase in both cell‐free and cell‐based assays. Structure–activity relationship analysis revealed that the secondary alcohol…
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Keywords:
inhibitors synthesis;
myxochelin inspired;
inspired lipoxygenase;
myxochelin ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.069
Abstract: This paper describes the rational development of a series of novel spiroindoline derivatives endowed with selective inhibitory activity on the HDAC6 isoform. A convenient multicomponent one-pot protocol was applied for the assembly of the desired…
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Keywords:
inhibitors synthesis;
hdac inhibitors;
novel spiroindoline;
spiroindoline hdac ... See more keywords
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Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2019.1706503
Abstract: Abstract A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which…
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Keywords:
inhibitors synthesis;
synthesis sar;
sar biological;
urease inhibitors ... See more keywords
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Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1054650
Abstract: Osthole is a natural coumarin compound which isolated from Cnidium monnieri (L.) Cusson, has extensive pharmacological activities and could be used as a leading compound for drug research and development. In a continuous effort to…
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Keywords:
molecular docking;
acetylcholinesterase inhibitors;
natural products;
inhibitors synthesis ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25071751
Abstract: Neurodegenerative diseases in which the decrease of the acetylcholine is observed are growing worldwide. In the present study, a series of new arylaminopropanone derivatives with N-phenylcarbamate moiety (1–16) were prepared as potential acetylcholinesterase and butyrylcholinesterase…
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Keywords:
inhibitors synthesis;
potential cholinesterase;
study;
arylaminopropanone derivatives ... See more keywords
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Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0242
Abstract: Aim: Synthesis of pyrazole derivatives as EGFR inhibitors. Materials & methods: Cytotoxicity and EGFR inhibitory effect were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and EGFR kits, respectively. The biodistribution of radioiodinated compound nanoparticles in tumor-bearing mice was…
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Keywords:
derivatives potent;
biodistribution;
egfr inhibitors;
inhibitors synthesis ... See more keywords