Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01161
Abstract: Aberrant activity of the histone methyltransferase polycomb repressive complex 2 (PRC2) has been linked to several cancers, with small-molecule inhibitors of the catalytic subunit of the PRC2 enhancer of zeste homologue 2 (EZH2) being recently… read more here.
Keywords: polycomb repressive; methyltransferase; repressive complex; subunit ... See more keywords
Abstract IA23: Using PARP inhibitors to target ATM-deficient cancers
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.dnarepair16-ia23
Abstract: The Ataxia-Telangiectasia Mutated (ATM) serine/threonine protein kinase plays an important role in orchestrating the cellular response to DNA double strand breaks (DSBs). Germline loss of ATM function results in Ataxia-Telangiectasia (A-T), a devastating childhood syndrome… read more here.
Keywords: parp inhibitors; using parp; cancer; atm deficient ... See more keywords
IDH Inhibitors Target Common Mutation in Glioma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nd2019-007
Abstract: Mutant-selective IDH1 inhibitors engage their target in the brain and shrink glioma tumors with an acceptable safety profile, according to phase I trial data on three different drug candidates. However, some clinicians argue the drug… read more here.
Keywords: target common; inhibitors target; glioma; mutation glioma ... See more keywords
Tyrosine Kinase Inhibitors Target B Lymphocytes
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DOI: 10.3390/biom13030438
Abstract: Autoimmune disorders and some types of blood cancer originate when B lymphocytes malfunction. In particular, when B cells produce antibodies recognizing the body’s proteins, it leads to various autoimmune disorders. Additionally, when B cells of… read more here.
Keywords: kinase inhibitors; plasma cells; kinase; inhibitors target ... See more keywords
Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells
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DOI: 10.3390/cancers11091359
Abstract: The CDH1 gene, encoding the cell adhesion protein E-cadherin, is one of the most frequently mutated genes in gastric cancer and inactivating germline CDH1 mutations are responsible for hereditary diffuse gastric cancer syndrome (HDGC). Using… read more here.
Keywords: cadherin deficient; akt inhibitors; gastric cancer; target synthetic ... See more keywords
Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16040580
Abstract: Alzheimer’s disease (AD) is the most common form of dementia. It increases the risk of other serious diseases and causes a huge impact on individuals, families, and socioeconomics. AD is a complex multifactorial disease, and… read more here.
Keywords: derived molecules; enzyme inhibitors; target alzheimer; inhibitors target ... See more keywords