Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2021.121822
Abstract: ABSTRACT Ferrocenyl and ruthenocenyl derivatives of ebselen are found to be competitive inhibitors of mammalian TrxR, with IC50 of 4.2 ± 0.3 and 2.5 ± 0.3 µM, respectively. The inhibition of TrxR is selective over… read more here.
Keywords: competitive inhibitors; derivatives ebselen; ebselen selective; inhibitors thioredoxin ... See more keywords
Potent Inhibitors of Thioredoxin Glutathione Reductase: Grail of Anti-Schistosome Drug within Reach?
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00072
Abstract: Species of the blood fluke Schistosoma are responsible for schistosomiasis, the second most common parasitic disease, which is prevalent particularly in poor communities. Under redox pressure, schistosomes survive in mammalian hosts with the help of… read more here.
Keywords: thioredoxin glutathione; inhibitors thioredoxin; glutathione reductase; drug ... See more keywords