Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26276
Abstract: Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of… read more here.
Keywords: mtor signaling; pharmacological inhibitors; potency mtor; mtor ... See more keywords
JAK inhibitors for the treatment of autoimmune and inflammatory diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2019.102390
Abstract: Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide… read more here.
Keywords: treatment autoimmune; inflammatory diseases; autoimmune inflammatory; inhibitors treatment ... See more keywords
[Place of PARP inhibitors in the treatment of endometrial and cervical cancers].
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2021.09.011
Abstract: New molecular therapeutic approaches have emerged in recent years for advanced gynaecological cancers, including targeted therapies such as poly-ADP-ribose polymerase inhibitors (PARPi). These have demonstrated efficacy in high-grade serous ovarian cancers in patients carrying a… read more here.
Keywords: parp inhibitors; cervical cancers; endometrial cervical; place parp ... See more keywords
Kinase inhibitors in the treatment of obstructive pulmonary diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2020.03.005
Abstract: Chronic pulmonary diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are major causes of death and reduced quality of life. Characteristic of chronic pulmonary disease is excessive lung inflammation that occurs in response to… read more here.
Keywords: kinase inhibitors; chronic pulmonary; obstructive pulmonary; pulmonary diseases ... See more keywords
Evaluating the role of aromatase inhibitors in the treatment of low-grade endometrial stromal sarcomas
Sign Up to like & getrecommendations! Published in 2022 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2022.100980
Abstract: Highlights • AIs may offer prolonged disease stability even in metastatic ESS, but response rates are modest.• After disease progression on one AI, some patients may benefit from trial of a different AI.• Optimal duration… read more here.
Keywords: role aromatase; low grade; aromatase inhibitors; inhibitors treatment ... See more keywords
New proteasome inhibitors in the treatment of multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Hematology, Transfusion and Cell Therapy"
DOI: 10.1016/j.htct.2018.07.003
Abstract: The treatment of patients with relapsed and/or refractory multiple myeloma has improved considerably in the last 15 years, after the introduction of proteasome inhibitors and immunomodulatory drugs. The first clinical trials with new proteasome inhibitors… read more here.
Keywords: multiple myeloma; proteasome inhibitors; inhibitors treatment; new proteasome ... See more keywords
Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
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DOI: 10.1021/acsinfecdis.0c00803
Abstract: Bumped kinase inhibitors (BKIs) that target Cryptosporidium parvum calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. Recently, BKI-1649, with a 7H-pyrrolo[2,3-d]pyrimidin-4-amine, or "pyrrolopyrimidine", central scaffold, has shown improved efficacy… read more here.
Keywords: kinase inhibitors; bumped kinase; pyrrolopyrimidine bumped; inhibitors treatment ... See more keywords
Effectiveness of ALK inhibitors in treatment of CNS metastases in NSCLC patients.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of medicine"
DOI: 10.1080/07853890.2023.2187077
Abstract: Metastases to the central nervous system (CNS) in patients with non-small cell lung cancer constitute an extremely difficult clinical problem, and their occurrence is associated with a poor prognosis. Due to the existence of the… read more here.
Keywords: alk inhibitors; nsclc patients; inhibitors treatment; cns metastases ... See more keywords
Evaluation of WO2017098421: GSK’s benzothiazine compounds as CD73 inhibitor filings
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2018.1407756
Abstract: ABSTRACT Introduction: There are considerable interests in the development of novel small-molecule CD73 inhibitors for the treatment of cancers, autoimmune diseases, precancerous syndromes, and other diseases associated with CD73 activity. Areas covered: The application claims… read more here.
Keywords: benzothiazine compounds; gsk benzothiazine; wo2017098421 gsk; cd73 inhibitors ... See more keywords
Immune checkpoint inhibitors for the treatment of sepsis:insights from preclinical and clinical development
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DOI: 10.1080/13543784.2022.2102477
Abstract: ABSTRACT Introduction It is now well established that sepsis induces a state of acquired immunosuppression, with an increased risk of secondary infections that contributes to patients’ worsening. Thus, tackling sepsis-induced immunosuppression represents a promising perspective.… read more here.
Keywords: sepsis; checkpoint inhibitors; immune checkpoint; inhibitors treatment ... See more keywords
Emerging protein kinase inhibitors for the treatment of rheumatoid arthritis
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DOI: 10.1080/14728214.2021.1964472
Abstract: ABSTRACT Introduction: Protein tyrosine kinase inhibitors are emergent drugs in the treatment of rheumatoid arthritis (RA); they block the signal transduction in immune cells preventing the production and release of pro-inflammatory cytokines. Areas covered: The… read more here.
Keywords: kinase inhibitors; kinase; treatment rheumatoid; rheumatoid arthritis ... See more keywords