Development of a fluorescence-based assay for screening of urate transporter 1 inhibitors using 6-carboxyfluorescein.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114246
Abstract: The urate transporter 1 (URAT1) inhibitors were considered a very promising class of uricosuric agents for the treatment of hyperuricemia and gout. In vitro activity testing of these compounds has been conducted by radio-labeling uric… read more here.
Keywords: inhibitors using; fluorescence based; development; urate transporter ... See more keywords
In silico exploration of aryl sulfonamide analogs as voltage-gated sodium channel 1.7 inhibitors by using 3D-QSAR, molecular docking study, and molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.10.009
Abstract: It has been demonstrated by human genetics that the voltage-gated sodium channel Nav1.7 is currently a promising target for the treatment of pain. In this research, we performed molecular simulation works on a series of… read more here.
Keywords: aryl sulfonamide; sodium channel; inhibitors using; gated sodium ... See more keywords
Detection and quantification of photosystem II inhibitors using the freshwater alga Desmodesmus subspicatus in combination with high-performance thin-layer chromatography.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental science & technology"
DOI: 10.1021/acs.est.9b04634
Abstract: We present a novel tool for detecting and monitoring photosystem II (PSII) inhibitors, using the freshwater alga Desmodesmus subspicatus, in environmental samples fractionated by high-performance thin-layer chromatography (HPTLC). After chromatographic separation of a sample on… read more here.
Keywords: detection; desmodesmus subspicatus; using freshwater; inhibitors using ... See more keywords
Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00670
Abstract: E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. These two proteins are involved in many cellular processes by acting as coactivators of a large number of… read more here.
Keywords: p300; proline based; p300 cbp; inhibitors using ... See more keywords