N‐Substituted piperidine‐3‐carbohydrazide‐hydrazones against Alzheimer's disease: Synthesis and evaluation of cholinesterase, beta‐amyloid inhibitory activity, and antioxidant capacity
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200519
Abstract: A series of piperidine‐3‐carbohydrazide‐hydrazones bearing phenylethyl, phenylpropyl, and phenylbutyl substituents on piperidine nitrogen were designed and synthesized as cholinesterase (ChE) inhibitors. The title compounds were screened for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) inhibitory activities and antioxidant… read more here.
Keywords: piperidine carbohydrazide; alzheimer disease; inhibitory activity; inhibitory ... See more keywords
OMIP‐106: A 30‐color panel for analysis of check‐point inhibitory networks in the bone marrow of acute myeloid leukemia patients
Sign Up to like & getrecommendations! Published in 2024 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24892
Abstract: Acute myeloid leukemia (AML) is the most common form of acute leukemia diagnosed in adults. Despite advances in medical care, the treatment of AML still faces many challenges, such as treatment‐related toxicities, that limit the… read more here.
Keywords: panel; acute myeloid; myeloid; myeloid leukemia ... See more keywords
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21958
Abstract: The recent emergence of drug‐resistant strains of Mycobacterium tuberculosis (Mtb) has complicated and significantly slowed efforts to eradicate and/or reduce the worldwide incidence of life‐threatening acute and chronic cases of tuberculosis. To overcome this setback,… read more here.
Keywords: thiophenylthiazole moiety; inha inhibitory; carrying thiophenylthiazole; inhibitory ... See more keywords
Synthesis of new N‐(5,6‐methylenedioxybenzothiazole‐2‐yl)‐2‐[(substituted)thio/piperazine]acetamide/propanamide derivatives and evaluation of their AChE, BChE, and BACE‐1 inhibitory activities
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.22214
Abstract: In this study, the synthesis of N‐(5,6‐methylenedioxybenzothiazole‐2‐yl)‐2‐[(substituted)thio/piperazine]acetamide/propanamide derivatives (3a‐3k) and to investigate their acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β‐secretase 1 (BACE‐1) inhibition activity were aimed. Mass, 1H NMR, and 13C NMR spectra were utilized to… read more here.
Keywords: bche; methylenedioxybenzothiazole substituted; bace; substituted thio ... See more keywords
Toxoplasma infection induces microglia-neuron contact and the loss of perisomatic inhibitory synapses.
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23816
Abstract: Infection and inflammation within the brain induces changes in neuronal connectivity and function. The intracellular protozoan parasite, Toxoplasma gondii, is one pathogen that infects the brain and can cause encephalitis and seizures. Persistent infection by… read more here.
Keywords: infection; inhibitory synapses; perisomatic inhibitory; inhibitory ... See more keywords
Hydrothermal treatment improves xanthine oxidase inhibitory activity and affects the polyphenol profile of Flos Sophorae Immaturus.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12215
Abstract: BACKGROUND Flos Sophorae Immaturus (FSI) is rich in polyphenols and becomes a potential uric acid-lowering food. However, the processing of FSI is greatly restricted due to the heat sensitivity and low solubility of polyphenols. In… read more here.
Keywords: hydrothermal treatment; flos sophorae; sophorae immaturus; inhibitory ... See more keywords
Purification and characterization of the dipeptidyl peptidase-IV inhibitory peptides from eel (Anguilla rostrata) scraps enzymatic hydrolysate for the treatment of Type 2 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12462
Abstract: BACKGROUND Type 2 diabetes mellitus (T2DM) is a serious threat to human health. Owing to the action of DPP-IV, the half-life of entero-insulin hormone after secretion is extremely short, causing insufficient insulin secretion in diabetic… read more here.
Keywords: rostrata scraps; anguilla rostrata; inhibitory; tyr pro ... See more keywords
Isolation and identification of angiotensin converting enzyme inhibitory peptides from Tartary buckwheat albumin (Isolation and identification of ACE inhibitory peptides from Tartary buckwheat albumin).
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12573
Abstract: BACKGROUND Tartary buckwheat protein peptides have been shown to be able to inhibit angiotensin-converting enzyme (ACE), but the exact protein type has been less studied for ACE activity inhibition, and only a few types of… read more here.
Keywords: inhibitory; ace inhibitory; tartary buckwheat; inhibitory peptides ... See more keywords
Design, synthesis and antifungal evaluation of novel nopol derivatives as potent laccase inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7426
Abstract: BACKGROUND To explore more potential natural product-based antifungal agents, a series of novel nopol-based carboxamide and hydrazide derivatives containing natural pinene structure was designed, synthesized, and evaluated for their inhibitory activities against seven phytopathogenic fungi… read more here.
Keywords: compound; zeae; novel nopol; inhibitory ... See more keywords
Cellular and pathophysiological consequences of Arp2/3 complex inhibition: role of inhibitory proteins and pharmacological compounds
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03128-y
Abstract: The actin-related protein complex 2/3 (Arp2/3) generates branched actin networks important for many cellular processes such as motility, vesicular trafficking, cytokinesis, and intercellular junction formation and stabilization. Activation of Arp2/3 requires interaction with actin nucleation-promoting… read more here.
Keywords: arp2; cellular pathophysiological; inhibitory proteins; inhibition ... See more keywords
Inhibitory control in neuronal networks relies on the extracellular matrix integrity
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03861-3
Abstract: Graphic abstract Inhibitory control is essential for the regulation of neuronal network activity, where excitatory and inhibitory synapses can act synergistically, reciprocally, and antagonistically. Sustained excitation-inhibition (E-I) balance, therefore, relies on the orchestrated adjustment of… read more here.
Keywords: synapse; inhibitory; inhibitory control; ecm ... See more keywords