In vitro inhibitory effects of some acetophenone derivatives on some metabolic enzymes and molecular docking
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000210
Abstract: In this study, the acetophenone derivatives 1–6 were found to be effective inhibitor molecules for α‐glycosidase, human carbonic anhydrases I and II (hCA I/II), and acetylcholinesterase (AChE), with Ki values in the range of 167.98 ± 25.06… read more here.
Keywords: inhibitory effects; vitro inhibitory; acetophenone derivatives; pdb ... See more keywords
Characterization of Glutathione S-Transferase Enzyme from Brown meagre (Sciaena umbra) and Inhibitory Effects of Heavy Metals.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2090
Abstract: Glutathione S-transferase (GST) detoxifies a broad spectrum of xenobiotics, especially in chemotherapeutic drugs, endogenous molecules and environmental pollutants. Since the enzyme metabolizes toxic compounds, it has been extensively studied in many living things including aquatic… read more here.
Keywords: inhibitory effects; meagre sciaena; sciaena umbra; brown meagre ... See more keywords
Synthesis of N‐Substituted Iminosugar Derivatives and Evaluation of Their Immunosuppressive Activities
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DOI: 10.1002/cmdc.201700706
Abstract: It is important to find more effective and safer immunosuppressants, because clinically used immunosuppressive agents have significant side effects. A series of N‐substituted iminosugar derivatives were designed and synthesized, and their immunosuppressive effects were evaluated… read more here.
Keywords: inhibitory effects; derivatives evaluation; substituted iminosugar; synthesis substituted ... See more keywords
Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29948
Abstract: Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) plays an important role. The… read more here.
Keywords: inhibitory effects; inflammatory; resorption; factor ... See more keywords
β-Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3-L1 Cell Maturation into Adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Lipids"
DOI: 10.1002/lipd.12234
Abstract: Studies have elucidated that pyrethroids induce adipogenesis. It is also known that macrophages can affect the homeostasis of adipose tissue. However, whether and how the β-cypermethrin (β-CYP)-mediated inhibition of the macrophages affects adipogenesis remain unknown.… read more here.
Keywords: raw 264; inhibitory effects; 264 cells; 3t3 cells ... See more keywords
Inhibitory effects of a smartphone‐controlled wearable transcutaneous tibial nerve stimulation device on bladder reflexes in anesthetized cats
Sign Up to like & getrecommendations! Published in 2022 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24876
Abstract: To explore the inhibitory effects of a novel, smartphone‐controlled, and wearable tibial nerve stimulation device on nonnociceptive and nociceptive bladder reflexes in anesthetized cats and to compare the stimulus results of two current waveforms outputted… read more here.
Keywords: inhibitory effects; controlled wearable; stimulation device; nerve stimulation ... See more keywords
Inhibitory effects of berberine on ovarian cancer: Beyond apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02763-0
Abstract: Ovarian cancer is one of the main causes of women’s mortality worldwide. A variety of biological mechanisms are involved in ovarian cancer pathogenesis, including epigenetic alterations, mutations (especially in tumor suppressor genes), upregulated oncogenes, decreased… read more here.
Keywords: ovarian cancer; cancer beyond; cancer; effects berberine ... See more keywords
Oleanane triterpenoids from Akebiae Caulis exhibit inhibitory effects on Aβ42 induced fibrillogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-016-0885-7
Abstract: Previous phytochemical investigations of Akebiae Caulis resulted in the isolation of triterpenes, triterpene glycosides, phenylethanoid glycosides and megastigmane glycoside. Amyloid beta (Aβ), the main component of the senile plaques detected in Alzheimer’s disease, induces cell… read more here.
Keywords: inhibitory effects; oleanane triterpenoids; induced fibrillogenesis; effects induced ... See more keywords
Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-017-0984-0
Abstract: A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1–6, 8–11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis… read more here.
Keywords: raw 264; inhibitory effects; production raw; tribulus terrestris ... See more keywords
Inhibitory effects of flavedo, albedo, fruits, and leaves of Citrus unshiu extracts on Streptococcus mutans.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2021.105056
Abstract: OBJECTVES Citrus unshiu has been shown to exhibit antimicrobial effects against citrus diseases. In the present study, C. unshiu was divided into flavedo, albedo, fruits, and leaves; the inhibitory effects of these extracts on Streptococcus… read more here.
Keywords: inhibitory effects; extracts streptococcus; citrus unshiu; albedo fruits ... See more keywords
Inhibitory effects of sulfamethoxazole on denitrifying granule properties: Short- and long-term tests.
Sign Up to like & getrecommendations! Published in 2017 at "Bioresource technology"
DOI: 10.1016/j.biortech.2017.02.102
Abstract: The broad-spectrum antibiotic sulfamethoxazole (SMX) was chosen to assess its short- and long-term effects on denitrifying granules. The SMX concentration and pre-exposure time in batch testing influenced the denitrifying granule activity. In the continuous-flow experiments,… read more here.
Keywords: inhibitory effects; term; denitrifying granule; long term ... See more keywords