Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad456
Abstract: Prime editing systems have enabled the incorporation of precise edits within a genome without introducing double strand breaks. Previous studies defined an optimal primer binding site (PBS) length for the pegRNA of ∼13 nucleotides depending… read more here.
Keywords: inhibitory interaction; pbs; auto inhibitory; prime editing ... See more keywords
Inhibitory interaction networks among coevolved Streptomyces populations from prairie soils
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223779
Abstract: Soil microbes live within highly complex communities, where community composition, function, and evolution are the product of diverse interactions among community members. Analysis of the complex networks of interactions within communities has the potential to… read more here.
Keywords: interaction networks; inhibitory interaction; among coevolved; networks among ... See more keywords