Inhibitory mechanism of lactoferrin on antibacterial activity of oenothein B: isothermal titration calorimetry and computational docking simulation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10271
Abstract: BACKGROUND Many foods contain proteins and polyphenols, but there is a poor understanding of the nature of the inhibitory effect of protein on the biologic activity of polyphenols. The inhibitory mechanism of the food protein… read more here.
Keywords: inhibitory mechanism; isothermal titration; antibacterial activity; lactoferrin antibacterial ... See more keywords
Targeting KRAS(G12C): From Inhibitory Mechanism to Modulation of Antitumor Effects in Patients
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.09.044
Abstract: KRAS mutations are among the most common genetic alterations in lung, colorectal, and pancreatic cancers. Direct inhibition of KRAS oncoproteins has been a long-standing pursuit in precision oncology, one established shortly after the discovery of… read more here.
Keywords: inhibitory mechanism; g12c inhibitory; targeting kras; mechanism modulation ... See more keywords
Inhibitory mechanism of 5-bromo-3-indoleacetic acid for non-structural-3 helicase hepatitis C virus with dynamics correlation network analysis
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.10.006
Abstract: Hepatitis C virus, Nonstructural 3 helicase (NS3h) protein is a well-studied segment of Non-structural 3/4 A helicase-protease protein that is crucial for the RNA duplex unwinding and RNA translocation during the process of HCV replication. Similar… read more here.
Keywords: inhibitory mechanism; non structural; rna binding; helicase ... See more keywords
Unraveling a Local Inhibitory Mechanism Safeguarding Regular Lateral Root Spacing.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.12.010
Abstract: The mechanisms underlying even spacing of lateral roots remains incompletely understood. In this issue of Developmental Cell, Toyokura et al. make an important step forward by showing how a local inhibitory mechanism involving a novel peptide… read more here.
Keywords: root spacing; inhibitory mechanism; local inhibitory; mechanism ... See more keywords
Inhibitory mechanism of cell-free supernatants of Lactobacillus plantarum on Proteus mirabilis and influence of the expression of histamine synthesis-related genes
Sign Up to like & getrecommendations! Published in 2021 at "Food Control"
DOI: 10.1016/j.foodcont.2021.107982
Abstract: Abstract The purpose of this study was to evaluate the inhibitory mechanism of cell-free supernatants of Lactobacillus plantarum (LCFS) on Proteus mirabilis and estimate the expression of histamine synthesis-related genes. The minimum inhibitory concentration (MIC)… read more here.
Keywords: expression; histamine; mechanism cell; inhibitory mechanism ... See more keywords
Insights into the inhibitory mechanism of purpurogallin on xanthine oxidase by multiple spectroscopic techniques and molecular docking
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129772
Abstract: Abstract Purpurogallin, a benzotropolone containing natural compound found in nutgall and oak bark, was investigated for its inhibitory mechanism on xanthine oxidase (XO) by multispectroscopic methods and molecular docking analysis. The enzyme kinetic analysis showed… read more here.
Keywords: mechanism purpurogallin; xanthine oxidase; inhibitory mechanism; purpurogallin ... See more keywords
Dissecting the Inhibitory Mechanism of the αB-Crystallin Domain against Aβ42 Aggregation and Its Effect on Aβ42 Protofibrils: A Molecular Dynamics Simulation Study.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00224
Abstract: Alzheimer's disease (AD) is related to the misfolding and aggregation of amyloid-β (Aβ) protein, and its major pathological hallmark is fibrillary β-amyloid plaques. Impeding the formation of Aβ β-structure-rich aggregates and dissociating Aβ fibrils are… read more here.
Keywords: aggregation; crystallin; effect; inhibitory mechanism ... See more keywords
A Neural Mechanism for Surprise-related Interruptions of Visuospatial Working Memory
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhw367
Abstract: Surprising perceptual events recruit a fronto-basal ganglia mechanism for inhibition, which suppresses motor activity following surprise. A recent study found that this inhibitory mechanism also disrupts the maintenance of verbal working memory (WM) after surprising… read more here.
Keywords: inhibitory mechanism; related interruptions; mechanism; surprise related ... See more keywords
Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11020168
Abstract: Alzheimer’s disease (AD) is the most prevalent chronic neurodegenerative disease in elderly individuals, causing dementia. Acetylcholinesterase (AChE) is regarded as one of the most popular drug targets for AD. Herbal secondary metabolites are frequently cited… read more here.
Keywords: simulation; ache; inhibitory mechanism; mechanism baicalein ... See more keywords
Inhibitory Mechanism of Advanced Glycation End-Product Formation by Avenanthramides Derived from Oats through Scavenging the Intermediates
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11121813
Abstract: As a special polyphenolic compound in oats, the physiological function of oat avenanthramides (AVAs) drives a variety of biological activities, and plays an important role in the prevention and treatment of common chronic diseases. In… read more here.
Keywords: advanced glycation; inhibitory mechanism; avas oats; glycation end ... See more keywords