Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma.
Sign Up to like & getrecommendations! Published in 2021 at "Nature immunology"
DOI: 10.1038/s41590-021-00943-z
Abstract: Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little about their underlying mechanisms or whether they could be… read more here.
Keywords: melanoma; immunity; molecule unleashes; inhibitory molecule ... See more keywords
Identification and characterization of new isoforms of human fas apoptotic inhibitory molecule (FAIM)
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185327
Abstract: Fas Apoptosis Inhibitory Molecule (FAIM) is an evolutionarily highly conserved death receptor antagonist, widely expressed and known to participate in physiological and pathological processes. Two FAIM transcript variants have been characterized to date, namely FAIM… read more here.
Keywords: faim; faim faim; inhibitory molecule; isoforms human ... See more keywords
Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.750578
Abstract: A number of neurodegenerative diseases are associated with the accumulation of misfolded proteins, including Alzheimer’s disease (AD). In AD, misfolded proteins such as tau and amyloid-β (Aβ) form pathological insoluble deposits. It is hypothesized that… read more here.
Keywords: inhibitory molecule; fas apoptosis; apoptosis inhibitory;