Going beyond a whack‐a‐mole game: A systems biology approach to immune tolerance
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Neuroimmunology"
DOI: 10.1111/cen3.12487
Abstract: In a recent article, the authors and colleagues identified a new gene module that is induced by the regulatory cytokine, interleukin-27 (IL-27), and is found in multiple non-responsive T-cell states, such as exhaustion, dysfunction and… read more here.
Keywords: inhibitory molecules; inhibitory; biology; gene module ... See more keywords
Aberrant Expressions of Co-stimulatory and Co-inhibitory Molecules in Autoimmune Diseases
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DOI: 10.3389/fimmu.2019.00261
Abstract: Co-signaling molecules include co-stimulatory and co-inhibitory molecules and play important roles in modulating immune responses. The roles of co-signaling molecules in autoimmune diseases have not been clearly defined. We assessed the expressions of co-stimulatory and… read more here.
Keywords: autoimmune diseases; inhibitory molecules; study; molecules autoimmune ... See more keywords
Increased Expression of Multiple Co-Inhibitory Molecules on Malaria-Induced CD8+ T Cells Are Associated With Increased Function Instead of Exhaustion
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DOI: 10.3389/fimmu.2022.878320
Abstract: Activated cytotoxic CD8+ T cells can selectively kill target cells in an antigen-specific manner. However, their prolonged activation often has detrimental effects on tissue homeostasis and function. Indeed, overwhelming cytotoxic activity of CD8+ T cells… read more here.
Keywords: cell; function; cd8 cells; inhibitory molecules ... See more keywords