Structural characteristics of coiled‐coil regions in AF10‐DOT1L and AF10‐inhibitory peptide complex
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0421-010r
Abstract: The interaction of the solo H3K79 methyltransferase DOT1‐like (DOT1L) and its regulatory factor ALL1‐fused gene from chromosome 10 protein (AF10) is crucial for the transcription of developmental genes such as HOXA in acute leukemia. The… read more here.
Keywords: dot1l af10; inhibitory peptide; coil regions; af10 inhibitory ... See more keywords
Isolation and Characterization of Angiotensin Converting Enzyme Inhibitory Peptide from Buffalo Casein
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10185-0
Abstract: Angiotensin-converting enzyme (ACE) enhances blood pressure by making potential vasoconstrictor, Angiotensin-II from Angiotensin-I. Thus, it is the key target enzyme in cardiovascular disease therapy. Hence, in the present study an attempt has been made for… read more here.
Keywords: casein; inhibitory peptide; converting enzyme; angiotensin converting ... See more keywords
Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano‐polyplexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.04.045
Abstract: ABSTRACT Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide‐polymer nano‐polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously‐described platform technology for intracellular peptide delivery and are formulated… read more here.
Keywords: post lyophilization; nps lyophilized; kinase inhibitory; lyophilization ... See more keywords
Structural analysis of ACE-inhibitory peptide (VL-9) derived from Kluyveromyces marxianus protein hydrolysate
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128199
Abstract: Abstract This study aimed to analyze the structural properties of VLSTSFPPK (VL-9) as an ACE-inhibitory peptide. Seven new peptide sequences were synthesized chemically using VL-9 sequence as a template. They were including, VLSTSFPPY(VY-9), VLSTSFPPW (VW-9),… read more here.
Keywords: structural analysis; inhibitory peptide; ace; ace inhibitory ... See more keywords
Improving Stability Enhances In Vivo Efficacy of a PCSK9 Inhibitory Peptide.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08029
Abstract: Optimization of peptide stability is essential for the development of peptides as bona fide alternatives to approved monoclonal antibodies. This is clearly the case for the many peptides reported to antagonize proprotein convertase subtilisin-like/kexin type… read more here.
Keywords: improving stability; activity; pcsk9 inhibitory; stability ... See more keywords
Effect of processing conditions and simulated gastrointestinal digestion on the activity of angiotensin I-converting enzyme (ACE) inhibitory peptide derived from duck meat hydrolysate
Sign Up to like & getrecommendations! Published in 2019 at "CyTA - Journal of Food"
DOI: 10.1080/19476337.2019.1575909
Abstract: ABSTRACT In this study, the ACE-inhibitory peptide ( read more here.
Keywords: peptide; ace inhibitory; digestion; inhibitory peptide ... See more keywords
Biopolymer-Delivered, Maternally Sequestered NF-κB (Nuclear Factor-κB) Inhibitory Peptide for Treatment of Preeclampsia.
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hypertensionaha.119.13368
Abstract: Preeclampsia is a hypertensive disorder of pregnancy that causes significant acute and long-term risk to the mother and the baby. The multifaceted maternal syndrome is driven by overproduction of circulating anti-angiogenic factors, widespread inflammation, and… read more here.
Keywords: inhibitory peptide; preeclampsia; maternally sequestered; nuclear factor ... See more keywords
Molecular docking and antihypertensive effects of a novel angiotensin-I converting enzyme inhibitory peptide from yak bone
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.993744
Abstract: A novel angiotensin-converting enzyme (ACE) inhibitory peptide ser-ala-ser-val-ile-pro-val-ser-ala-val-arg-ala (SASVIPVSAVRA) was purified and identified from yak bone by Electrospray Ionization-Time of Flight-Mass Spectrometry (ESI-TOF-MS). Results in vitro showed that the peptide exhibited strong ACE inhibition activities… read more here.
Keywords: converting enzyme; ala; novel angiotensin; peptide ... See more keywords
Inhibitory Peptide of Soluble Guanylyl Cyclase/Trx1 Interface Blunts the Dual Redox Signaling Functions of the Complex
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040906
Abstract: Soluble guanylyl cyclase (GC1) and oxido-reductase thioredoxin (Trx1) form a complex that mediates two NO signaling pathways as a function of the redox state of cells. Under physiological conditions, reduced Trx1 (rTrx1) supports the canonical… read more here.
Keywords: soluble guanylyl; guanylyl cyclase; activity; gc1 ... See more keywords
Purification and Identification of a Novel Angiotensin Converting Enzyme Inhibitory Peptide from the Enzymatic Hydrolysate of Lepidotrigla microptera
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11131889
Abstract: In this study, Lepidotrigla microptera were hydrolyzed with four different proteolytic enzymes (Papain, neutrase, flavourzyme, and alcalase), and their distribution of molecular weights and ACE-inhibitory activity were tested. The alcalase hydrolysates showed the maximum ACE-inhibitory… read more here.
Keywords: microptera; lepidotrigla microptera; ace inhibitory; hydrolysate lepidotrigla ... See more keywords
Identification of an ACE-Inhibitory Peptide from Walnut Protein and Its Evaluation of the Inhibitory Mechanism
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19041156
Abstract: In the present study, a novel angiotensin I-converting enzyme inhibitory (ACE inhibitory) peptide, EPNGLLLPQY, derived from walnut seed storage protein, fragment residues 80–89, was identified by ultra-high performance liquid chromatography electrospray ionization quadrupole time of… read more here.
Keywords: inhibitory peptide; ace; walnut protein; ace inhibitory ... See more keywords