Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore.
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DOI: 10.1021/acs.jmedchem.1c01989.s001
Abstract: Upregulation of ATP binding cassette (ABC) transporter efflux pumps (i.e. P-glycoprotein, P-gp) can impart multidrug resistance, rendering many chemotherapeutics ineffective and seriously limiting treatment regimes. While ABC transporters remain an attractive target for therapeutic intervention,… read more here.
Keywords: directed biosynthesis; inhibitory pharmacophore; precursor directed; marine derived ... See more keywords