Synthesis of alpha amylase inhibitors based on privileged indole scaffold.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.04.010
Abstract: Twenty five derivatives of indole carbohydrazide (1-25) had been synthesized. These compounds were characterized using 1H NMR and EI-MS, and further evaluated for their α-amylase inhibitory potential. The analogs (1-25) showed varying degree of α-amylase… read more here.
Keywords: inhibitory potential; amylase inhibitors; alpha amylase; amylase ... See more keywords
Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.08.003
Abstract: α-Amylase is a target for type-2 diabetes mellitus treatment. However, small molecule inhibitors of α-amylase are currently scarce. In the course of developing small molecule α-amylase inhibitors, we designed and synthesized thiadiazole quinoline analogs (1-30),… read more here.
Keywords: thiadiazole quinoline; amylase inhibitory; inhibitory potential; amylase ... See more keywords
Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.03.022
Abstract: α-Glucosidase is a catabolic enzyme that regulates the body's plasma glucose levels by providing energy sources to maintain healthy functioning. 2-Amino-thiadiazole (1-13) and 2-amino-thiadiazole based Schiff bases (14-22) were synthesized, characterized by 1H NMR and… read more here.
Keywords: vitro glucosidase; inhibitory potential; synthesis vitro; glucosidase ... See more keywords
New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103284
Abstract: New triazinoindole bearing thiazole/oxazole analogues (1-21) were synthesized and characterized through spectroscopic techniques such as HREI-MS, 1H and 13C NMR. The configuration of compound 2i and 2k was confirmed through NOESY. All analogues were evaluated… read more here.
Keywords: inhibitory potential; thiazole oxazole; amylase inhibitory; new triazinoindole ... See more keywords
Synthesis, α-glycosidase inhibitory potential and molecular docking study of benzimidazole derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103555
Abstract: A series of twenty-six analogs of benzimidazole based oxadiazole have been synthesized and evaluated against alpha-glycosidase enzyme. Most the analogs showed excellent to good inhibitory potential. Among the screened analogs, analog 1, 2, 3 and… read more here.
Keywords: glycosidase inhibitory; inhibitory potential; docking study; synthesis glycosidase ... See more keywords
Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.06.078
Abstract: Microtubule affinity regulating kinase (MARK4) is currently being considered as a potential drug target for diabetes, cancer, and neurodegenerative diseases. Since the role of MARK4 in the phosphorylation of tau protein and subsequently Alzheimer's disease… read more here.
Keywords: mark4 inhibitory; inhibitory potential; cha; neurodegenerative diseases ... See more keywords
Inhibitory potential of EGCG on Streptococcus mutans biofilm: A new approach to prevent Cariogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104129
Abstract: Dental caries is a common cause for tooth loss and Streptococcus mutans is identified as the etiologic pathogen. This study evaluates the inhibitory potential of Epigallocatechin gallate (EGCG) on S.mutans glucansucrase enzyme and its biofilm.… read more here.
Keywords: inhibitory potential; mutans biofilm; potential egcg; egcg ... See more keywords
An in-vitro elucidation of inhibitory potential of carminic acid: Possible therapeutic approach for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.112692
Abstract: Abstract Protein misfolding leads to several human pathologies. So far, there has not been much success on the remediations of these protein conformational disorders. Since these diseases arise as a result of protein aggregation, hence… read more here.
Keywords: inhibitory potential; elucidation inhibitory; carminic acid; vitro elucidation ... See more keywords
Inhibitory Potential of Red Cabbage against Digestive Enzymes Linked to Obesity and Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b02499
Abstract: Assays of the inhibitory potential against enzymes involved in carbohydrate and lipid digestion (α-amylase, α-glucosidase, and lipase) as well as the total contents of phenolics and anthocyanins, anthocyanin profile, and antioxidant capacity revealed significant differences… read more here.
Keywords: antioxidant capacity; inhibitory potential; potential red; inhibitory activity ... See more keywords
Decipher the inhibitory potential of phytocompounds from Leptadenia reticulata on dopamine D2 receptor to enhance prolactin secretion.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1735-2887
Abstract: Dopamine is secreted by the hypothalamus, which inhibits the proliferation and effectiveness of lactotroph cells that release prolactin via dopamine D2 receptor (D2R). D2R activation inhibits lactotroph cell prolactin synthesis and regulates prolactin gene expression.… read more here.
Keywords: breast milk; inhibitory potential; dopamine receptor; d2r ... See more keywords
Determination of precipitation inhibitory potential of polymers from amorphous solid dispersions
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1503295
Abstract: Abstract Precipitation inhibitory potential of polymers screened from precipitation study may be altered once it is formulated in amorphous solid dispersions (ASDs). Objective: Present study was embarked with an objective to determine whether the polymers… read more here.
Keywords: hpmc hpmc; inhibitory potential; hpmc; precipitation ... See more keywords