NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of cancer"
DOI: 10.1002/ijc.33859
Abstract: The surface inhibitory receptor NKG2A forms heterodimers with the invariant CD94 chain and is expressed on a subset of activated CD8 T cells. As antibodies to block NKG2A are currently tested in several efficacy trials… read more here.
Keywords: cd8; inhibitory receptor; cd8 cells; nkg2a late ... See more keywords
The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells
Sign Up to like & getrecommendations! Published in 2025 at "Nature Immunology"
DOI: 10.1038/s41590-025-02300-w
Abstract: The co-inhibitory receptor TIGIT suppresses excessive immune responses in autoimmune conditions while also restraining antitumor immunity. In viral infections, TIGIT alone does not affect viral control but has been shown to limit tissue pathology. However,… read more here.
Keywords: receptor; pathology; receptor tigit; tigit ... See more keywords
THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2318773121
Abstract: Significance Therapies based on immune checkpoint blockades have revolutionized the field of cancer immunotherapy, yet the molecular mechanism underlying the signaling activity of these receptors remains ill-defined. Here, we show that the T cell lineage… read more here.
Keywords: themis promotes; cell development; promotes cell; btla ... See more keywords
A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets
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DOI: 10.1101/2023.10.24.563834
Abstract: Blocking inhibitory receptors like PD-1 and CTLA-4 has revolutionized cancer treatment in recent years. However, despite major successes in melanoma and lung cancer, the majority of cancer types are not responsive to these immunotherapies. As… read more here.
Keywords: inhibitory receptors; pipeline; novel inhibitory; immune inhibitory ... See more keywords
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A
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DOI: 10.1111/imr.13174
Abstract: Neutrophils are the first leukocytes recruited from the circulation in response to invading pathogens or injured cells. To eradicate pathogens and contribute to tissue repair, recruited neutrophils generate and release a host of toxic chemicals… read more here.
Keywords: response; receptor function; inhibitory receptor; understanding inhibitory ... See more keywords
Inhibitory Receptor Diffusion Dynamics
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DOI: 10.3389/fnmol.2019.00313
Abstract: The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma… read more here.
Keywords: receptor; diffusion dynamics; receptor diffusion; inhibitory receptor ... See more keywords
Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910207
Abstract: CLEC12A is a myeloid inhibitory receptor that negatively regulates inflammation in mouse models of autoimmune and autoinflammatory arthritis. Reduced CLEC12A expression enhances myeloid cell activation and inflammation in CLEC12A knock-out mice with collagen antibody-induced or… read more here.
Keywords: expression; oligomerisation signaling; clec12a; inhibitory receptor ... See more keywords