Sensing context: Inhibitory receptors on non‐hematopoietic cells
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250306
Abstract: Similar to immune cells, non‐hematopoietic cells recognize microbial and endogenous threats. Their response to these stimuli is dependent on the environmental context. For example, intact intestinal epithelium expresses pattern recognition receptors (PRRs) but should tolerate… read more here.
Keywords: receptors non; hematopoietic cells; inhibitory receptors; non hematopoietic ... See more keywords
Tim-3, Lag-3, and TIGIT.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2017_62
Abstract: Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against… read more here.
Keywords: inhibitory receptors; lag tigit; tim lag;
The inhibitory receptors on NK cells and CTLs are upregulated in adult and adolescent patients with secondary hemophagocytic lymphohistiocytosis.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.03.006
Abstract: Hemophagocytic lymphohistiocytosis (HLH) includes primary HLH (pHLH) and secondary HLH (sHLH). Mutations that cause abnormal functions in natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are frequently identified in pHLH. However, why NK cells… read more here.
Keywords: cells ctls; hemophagocytic lymphohistiocytosis; expression; inhibitory receptors ... See more keywords
Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "European urology"
DOI: 10.1016/j.eururo.2016.10.009
Abstract: Blockade of inhibitory receptors (IRs) overexpressed by T cells can activate antitumor immune responses, resulting in the most promising therapeutic approaches, particularly in bladder cancer, currently able to extend patient survival. Thanks to their ability… read more here.
Keywords: cell; dcs; btla tim; cancer ... See more keywords
Aberrant expression of inhibitory receptors on B cells in patients with Graves' disease.
Sign Up to like & getrecommendations! Published in 2021 at "Human immunology"
DOI: 10.1016/j.humimm.2021.12.001
Abstract: The pathophysiological mechanism underlying Graves' disease (GD) remains incompletely understood. Inhibitory receptors on B cells are critical for humoral immunity, which plays a key role in GD pathogenesis. This study aimed to investigate B cell… read more here.
Keywords: expression; graves disease; inhibitory receptors; receptors cells ... See more keywords
Effects of tacrolimus (FK506) and mycophenolate mofetil (MMF) on regulatory T cells and co-inhibitory receptors in the peripheral blood of human liver allograft patients
Sign Up to like & getrecommendations! Published in 2019 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2018.1533026
Abstract: Abstract Context: Recent studies have shown that a combination treatment of mycophenolate mofetil (MMF) and tacrolimus (FK506) may be an option for organ transplantation patients. Objective: In this study, we detected the effects of FK506… read more here.
Keywords: fk506 mmf; inhibitory receptors; group; fk506 group ... See more keywords
A variety of 'exhausted' T cells in the tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac013
Abstract: In T cell biology, 'exhaustion' was initially described as a hyporesponsive state in CD8 + T cells during chronic infections. Recently, exhaustion has been recognized as a T-cell dysfunctional state in the tumor microenvironment (TME).… read more here.
Keywords: cell; inhibitory receptors; exhaustion; variety ... See more keywords
Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba6493
Abstract: Atypical memory B cell antigens must be membrane associated to force exclusion of inhibitory receptors from the immune synapse. Chronic human infectious diseases, including malaria, are associated with a large expansion of a phenotypically and… read more here.
Keywords: responses membrane; infectious diseases; chronic human; human infectious ... See more keywords
P169 Activated effector T cells co-expressing multiple inhibitory receptors are enriched in the tumor immune microenvironment of HGSOC expressing high and uniform WT-1 antigen
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.230
Abstract: Introduction/Background In high grade serous ovarian cancer(HGSOC),the association between tumor-infiltrating lymphocytes(TILs)and survival suggests a role for T cell immune surveillance. Despite this, initial attempts with PD1 checkpoint blockade and adoptive T-cell therapy(ACT) had limited efficacy.… read more here.
Keywords: expression; antigen; tumor; inhibitory receptors ... See more keywords
Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00019
Abstract: Human immunodeficiency virus type-1 (HIV-1) elite controllers (ELCs) represent a unique population that control viral replication in the absence of antiretroviral therapy (cART). It is well established that expression of multiple inhibitory receptors on CD8+… read more here.
Keywords: human immunodeficiency; cd4 cells; cell; expression ... See more keywords
Inhibitory Receptor Crosslinking Quantitatively Dampens Calcium Flux Induced by Activating Receptor Triggering in NK Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03173
Abstract: Natural killer (NK) cell function is regulated by a balance between activating and inhibitory receptors, but the details of this receptor interplay are not extensively understood. We developed a flow cytometry-based assay system in which… read more here.
Keywords: activating receptor; receptor triggering; ca2 flux; receptor ... See more keywords