Programmed Death Ligand-1-Overexpressing Donor Exosomes Mediate Donor-Specific Immunosuppression by Delivering Co-inhibitory Signals to Donor-Specific T Cells.
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DOI: 10.1002/adhm.202300670
Abstract: Programmed death ligand-1 (PD-L1) and donor antigens are critical for donor immature dendritic cells (DCs) targeting donor-specific T cells to induce transplant tolerance. This study aimed to clarify whether DC-derived exosomes (DEX) with donor antigens… read more here.
Keywords: inhibitory signals; specific cells; donor specific; donor ... See more keywords
Combining Enhancement of Inhibitory Signals and Blockade of Co-Stimulation to Modulate Human Anti-Pig Immune Responses
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DOI: 10.1097/01.tp.0000543722.75155.57
Abstract: Introduction Transgenic expression of human modulatory molecules in pigs is a promising approach to prevent human anti-porcine immune responses and thus, an important step on the way to clinical xenotransplantation. We have previously shown that… read more here.
Keywords: stimulation; lea29y; inhibitory signals; l23 ... See more keywords