Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.015
Abstract: Normal brain functions depend on the balanced development of excitatory and inhibitory synapses. Our knowledge of the molecular mechanisms underlying inhibitory synapse formation is limited. Neuroligin-2 (NL2), a transmembrane protein at inhibitory postsynaptic sites, is… read more here.
Keywords: lhfpl4 garlh4; inhibitory synapse; synapse formation; nl2 binding ... See more keywords
Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1110986
Abstract: Malformation of cortical development (MCD) is a family of neurodevelopmental disorders, which usually manifest with intellectual disability and early-life epileptic seizures. Mutations in genes encoding microtubules (MT) and MT-associated proteins are one of the most… read more here.
Keywords: synapse dysfunction; deletion; dysfunction epileptic; susceptibility ... See more keywords