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   Articles with "inhibitory synapses" as a keyword



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Toxoplasma infection induces microglia-neuron contact and the loss of perisomatic inhibitory synapses.

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recommendations! Published in 2020 at "Glia"

DOI: 10.1002/glia.23816

Abstract: Infection and inflammation within the brain induces changes in neuronal connectivity and function. The intracellular protozoan parasite, Toxoplasma gondii, is one pathogen that infects the brain and can cause encephalitis and seizures. Persistent infection by… read more here.

Keywords: infection; inhibitory synapses; perisomatic inhibitory; inhibitory ... See more keywords
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Selective Extracellular Stimulation of Pharmacologically Distinct CCK/CB1R Positive Interneuron to Pyramidal Cell Perisomatic Inhibitory Synapses

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recommendations! Published in 2017 at "BioNanoScience"

DOI: 10.1007/s12668-016-0310-1

Abstract: During prolonged whole cell recording, the intracellular contents are progressively dialyzed with the pipette solution; this often leads to significant changes in synaptic efficacy. To overcome this problem, we developed an approach allowing reliable extracellular… read more here.

Keywords: pyramidal; extracellular stimulation; stimulation; inhibitory synapses ... See more keywords
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Reciprocal stabilisation of glycine receptors and gephyrin scaffold proteins at inhibitory synapses.

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recommendations! Published in 2021 at "Biophysical journal"

DOI: 10.1016/j.bpj.2021.01.024

Abstract: Postsynaptic scaffold proteins immobilise neurotransmitter receptors in the synaptic membrane opposite to presynaptic vesicle release sites, thus ensuring efficient synaptic transmission. At inhibitory synapses in the spinal cord, the main scaffold protein gephyrin assembles in… read more here.

Keywords: inhibitory synapses; scaffold proteins; glycine receptors; gephyrin ... See more keywords
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Pathogenic role of autoantibodies against inhibitory synapses

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.09.009

Abstract: Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies… read more here.

Keywords: inhibitory synapses; autoantibodies inhibitory; pathogenic role; role autoantibodies ... See more keywords

Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.03.078

Abstract: Dendritic inhibitory synapses are most efficient in modulating excitatory inputs localized on the same dendrite, but it is unknown whether their location is random or regulated. Here, we show that the formation of inhibitory synapses… read more here.

Keywords: mediates local; signaling mediates; excitatory; endocannabinoid signaling ... See more keywords

Fractional occupancy of synaptic binding sites and the molecular plasticity of inhibitory synapses

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recommendations! Published in 2020 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2019.01.008

Abstract: The postsynaptic density (PSD) at inhibitory synapses is a complex molecular assembly that serves as a platform for the interaction of neurotransmitter receptors, scaffold and adapter proteins, cytoskeletal elements and signalling molecules. The stability of… read more here.

Keywords: synaptic binding; inhibitory synapses; binding sites; fractional occupancy ... See more keywords
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Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses.

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recommendations! Published in 2020 at "Nature neuroscience"

DOI: 10.1038/s41593-020-00729-w

Abstract: Information processing in the brain depends on specialized organization of neurotransmitter receptors and scaffolding proteins within the postsynaptic density. However, how these molecules are organized in situ remains largely unknown. In this study, template-free classification… read more here.

Keywords: mesophasic organization; inhibitory synapses; gabaa receptors; receptors hippocampal ... See more keywords

Cholecystokinin-expressing GABA neurons elicit long-term potentiation in the cortical inhibitory synapses and attenuate sound-shock associative memory

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-025-17065-3

Abstract: Neuronal interactions between inhibitory and excitatory neurons play a pivotal role in regulating the balance of excitation and inhibition in the central nervous system (CNS). Consequently, the efficacy of inhibitory/excitatory synapses profoundly affects neural network… read more here.

Keywords: memory; long term; cortical inhibitory; term potentiation ... See more keywords

Distinct mechanisms control the specific synaptic functions of Neuroligin 1 and Neuroligin 2

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recommendations! Published in 2025 at "EMBO Reports"

DOI: 10.1038/s44319-024-00286-4

Abstract: Neuroligins are postsynaptic cell-adhesion molecules that regulate synaptic function with a remarkable isoform specificity. Although Nlgn1 and Nlgn2 are highly homologous and biochemically interact with the same extra- and intracellular proteins, Nlgn1 selectively functions in… read more here.

Keywords: excitatory inhibitory; function; specificity; inhibitory synapses ... See more keywords

Inhibitory synapses mimicking in flexible protonic/electronic hybrid rectifying devices gating by chitosan electrolyte

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recommendations! Published in 2018 at "Electronics Letters"

DOI: 10.1049/el.2018.5136

Abstract: Flexible protonic/electronic hybrid rectifying devices gating by chitosan electrolyte were fabricated on polyethylene terephthalate (PET) substrate. indium zinc oxide (IZO) source/drain electrodes with a self-assembled IZO channel were prepared by RF sputtering with a nickel… read more here.

Keywords: protonic electronic; rectifying devices; electronic hybrid; inhibitory synapses ... See more keywords

High-affinity detection of biotinylated endogenous neuroligin-1 at excitatory and inhibitory synapses using a tagged knock-in mouse

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2411669122

Abstract: Significance The formation of synapses, the communication nodes between neurons, is of utmost importance in brain development. Adhesion molecules including neuroligins (NLGNs) play important roles in this process by providing a linkage between pre- and… read more here.

Keywords: excitatory inhibitory; high affinity; inhibitory synapses; mouse ... See more keywords