Toxoplasma infection induces microglia-neuron contact and the loss of perisomatic inhibitory synapses.
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23816
Abstract: Infection and inflammation within the brain induces changes in neuronal connectivity and function. The intracellular protozoan parasite, Toxoplasma gondii, is one pathogen that infects the brain and can cause encephalitis and seizures. Persistent infection by… read more here.
Keywords: infection; inhibitory synapses; perisomatic inhibitory; inhibitory ... See more keywords
Selective Extracellular Stimulation of Pharmacologically Distinct CCK/CB1R Positive Interneuron to Pyramidal Cell Perisomatic Inhibitory Synapses
Sign Up to like & getrecommendations! Published in 2017 at "BioNanoScience"
DOI: 10.1007/s12668-016-0310-1
Abstract: During prolonged whole cell recording, the intracellular contents are progressively dialyzed with the pipette solution; this often leads to significant changes in synaptic efficacy. To overcome this problem, we developed an approach allowing reliable extracellular… read more here.
Keywords: pyramidal; extracellular stimulation; stimulation; inhibitory synapses ... See more keywords
Reciprocal stabilisation of glycine receptors and gephyrin scaffold proteins at inhibitory synapses.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.01.024
Abstract: Postsynaptic scaffold proteins immobilise neurotransmitter receptors in the synaptic membrane opposite to presynaptic vesicle release sites, thus ensuring efficient synaptic transmission. At inhibitory synapses in the spinal cord, the main scaffold protein gephyrin assembles in… read more here.
Keywords: inhibitory synapses; scaffold proteins; glycine receptors; gephyrin ... See more keywords
Pathogenic role of autoantibodies against inhibitory synapses
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.09.009
Abstract: Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies… read more here.
Keywords: inhibitory synapses; autoantibodies inhibitory; pathogenic role; role autoantibodies ... See more keywords
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
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DOI: 10.1016/j.celrep.2019.03.078
Abstract: Dendritic inhibitory synapses are most efficient in modulating excitatory inputs localized on the same dendrite, but it is unknown whether their location is random or regulated. Here, we show that the formation of inhibitory synapses… read more here.
Keywords: mediates local; signaling mediates; excitatory; endocannabinoid signaling ... See more keywords
Fractional occupancy of synaptic binding sites and the molecular plasticity of inhibitory synapses
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.01.008
Abstract: The postsynaptic density (PSD) at inhibitory synapses is a complex molecular assembly that serves as a platform for the interaction of neurotransmitter receptors, scaffold and adapter proteins, cytoskeletal elements and signalling molecules. The stability of… read more here.
Keywords: synaptic binding; inhibitory synapses; binding sites; fractional occupancy ... See more keywords
Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses.
Sign Up to like & getrecommendations! Published in 2020 at "Nature neuroscience"
DOI: 10.1038/s41593-020-00729-w
Abstract: Information processing in the brain depends on specialized organization of neurotransmitter receptors and scaffolding proteins within the postsynaptic density. However, how these molecules are organized in situ remains largely unknown. In this study, template-free classification… read more here.
Keywords: mesophasic organization; inhibitory synapses; gabaa receptors; receptors hippocampal ... See more keywords
Inhibitory synapses mimicking in flexible protonic/electronic hybrid rectifying devices gating by chitosan electrolyte
Sign Up to like & getrecommendations! Published in 2018 at "Electronics Letters"
DOI: 10.1049/el.2018.5136
Abstract: Flexible protonic/electronic hybrid rectifying devices gating by chitosan electrolyte were fabricated on polyethylene terephthalate (PET) substrate. indium zinc oxide (IZO) source/drain electrodes with a self-assembled IZO channel were prepared by RF sputtering with a nickel… read more here.
Keywords: protonic electronic; rectifying devices; electronic hybrid; inhibitory synapses ... See more keywords
TNF-α Orchestrates Experience-Dependent Plasticity of Excitatory and Inhibitory Synapses in the Anterior Piriform Cortex
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.824454
Abstract: Homeostatic synaptic plasticity, which induces compensatory modulation of synapses, plays a critical role in maintaining neuronal circuit function in response to changing activity patterns. Activity in the anterior piriform cortex (APC) is largely driven by… read more here.
Keywords: tnf; excitatory inhibitory; inhibitory synapses; plasticity ... See more keywords
Roles of Glial Cells in Sculpting Inhibitory Synapses and Neural Circuits
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00381
Abstract: Glial cells are essential for every aspect of normal neuronal development, synapse formation, and function in the central nervous system (CNS). Astrocytes secrete a variety of factors that regulate synaptic connectivity and circuit formation. Microglia… read more here.
Keywords: synapses neural; glial cells; inhibitory synapses; roles glial ... See more keywords