Correlating Fluorescence and High-Resolution Scanning Electron Microscopy (HRSEM) for the study of GABAA receptor clustering induced by inhibitory synaptic plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14210-5
Abstract: Both excitatory and inhibitory synaptic contacts display activity dependent dynamic changes in their efficacy that are globally termed synaptic plasticity. Although the molecular mechanisms underlying glutamatergic synaptic plasticity have been extensively investigated and described, those… read more here.
Keywords: high resolution; inhibitory synaptic; microscopy; synaptic plasticity ... See more keywords
miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Reports"
DOI: 10.1038/s44319-024-00253-z
Abstract: Activity-dependent protein synthesis is crucial for long-lasting forms of synaptic plasticity. However, our understanding of translational mechanisms controlling GABAergic synapses is limited. One distinct form of inhibitory long-term potentiation (iLTP) enhances postsynaptic clusters of GABAARs… read more here.
Keywords: iltp; plasticity; synthesis; translation ... See more keywords
Inhibitory Synaptic Supercapacitor With Bidirectional and Tunable Plasticity
Sign Up to like & getrecommendations! Published in 2025 at "IEEE Transactions on Electron Devices"
DOI: 10.1109/ted.2025.3602031
Abstract: Artificial synapse with bidirectional inhibitory plasticity is critical for neuromorphic engineering. However, conventional synaptic devices, such as memristors and transistors, typically exhibit only unidirectional inhibitory plasticity. Herein, we present an inhibitory synaptic supercapacitor based on… read more here.
Keywords: voltage; synaptic supercapacitor; inhibitory synaptic; plasticity ... See more keywords
The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14907
Abstract: GABAergic interneurons are highly diverse, and their synaptic outputs express various forms of plasticity. Compelling evidence indicates that activity‐dependent changes of inhibitory synaptic transmission play a significant role in regulating neural circuits critically involved in… read more here.
Keywords: inhibitory synaptic; forms plasticity; molecular mechanisms; synaptic plasticity ... See more keywords
Properties of Deiters' neurons and inhibitory synaptic transmission in the mouse lateral vestibular nucleus.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00016.2022
Abstract: Deiters' neurons, located exclusively in the lateral vestibular nucleus (LVN), are involved in vestibulospinal reflexes, innervate extensor motoneurons that drive anti-gravity muscles, and receive inhibitory inputs from the cerebellum. We investigated intrinsic membrane properties, short-term… read more here.
Keywords: non deiters; lateral vestibular; vestibular nucleus; inhibitory synaptic ... See more keywords
Exploring sex differences in inhibitory synaptic transmission in the kolliker-fuse of rett syndrome mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731530
Abstract: Rett Syndrome (RTT) is a rare neurodevelopmental disorder characterized by severe motor impairments including breathing problems. RTT is caused by mutations in the methyl CpG binding protein 2 (MeCP2) gene located on the X chromosome.… read more here.
Keywords: synaptic transmission; rett syndrome; physiology; inhibitory synaptic ... See more keywords
The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model
Sign Up to like & getrecommendations! Published in 2024 at "Microbiome"
DOI: 10.1186/s40168-024-01755-7
Abstract: Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ + / - ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders. However its pathogenic mechanism remains unclear,… read more here.
Keywords: propionic acid; indole propionic; microdeletion; gut ... See more keywords
Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0306423
Abstract: Hyperexcitability of motor neurons and spinal cord motor circuitry has been widely reported in the early stages of Amyotrophic Lateral Sclerosis (ALS). Changes in the relative amount of excitatory to inhibitory inputs onto a neuron… read more here.
Keywords: excitatory inhibitory; ratios unchanged; hyperexcitability; synaptic ratios ... See more keywords
Heterogeneous Responses to Changes in Inhibitory Synaptic Strength in Networks of Spiking Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.785207
Abstract: How does the dynamics of neurons in a network respond to changes in synaptic weights? Answer to this question would be important for a full understanding of synaptic plasticity. In this article, we report our… read more here.
Keywords: strength; network; synaptic strength; synaptic weights ... See more keywords
Genetic background determines synaptic phenotypes in Arid1b-mutant mice
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2023.1341348
Abstract: ARID1B, a chromatin remodeler, is strongly implicated in autism spectrum disorders (ASD). Two previous studies on Arid1b-mutant mice with the same exon 5 deletion in different genetic backgrounds revealed distinct synaptic phenotypes underlying the behavioral… read more here.
Keywords: mice; pyramidal neurons; mutant mice; arid1b mutant ... See more keywords
Inhibitory Synaptic Influences on Developmental Motor Disorders
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24086962
Abstract: During development, GABA and glycine play major trophic and synaptic roles in the establishment of the neuromotor system. In this review, we summarise the formation, function and maturation of GABAergic and glycinergic synapses within neuromotor… read more here.
Keywords: influences developmental; rett syndrome; synaptic influences; inhibitory synaptic ... See more keywords