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Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.07.007
Abstract: The pathology of Parkinson's disease and other synucleinopathies is characterized by the formation of intracellular inclusions comprised primarily of misfolded, fibrillar α-synuclein (α-syn). One strategy to slow disease progression is to prevent the misfolding and…
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Keywords:
aggregation;
inhibits aggregation;
enhancing reconfiguration;
pathology ... See more keywords
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Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00071
Abstract: Aβ peptide and hyper-phosphorylated microtubule associated protein (Tau) aggregation causes severe damage to both the neuron membrane and key signal processing microfilament (microtubule) in Alzheimer's disease (AD) brains. To date, the key challenge is to…
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Keywords:
ache;
inhibits aggregation;
neuroprotective peptoid;
peptoid ... See more keywords
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Published in 2023 at "Protein and peptide letters"
DOI: 10.2174/0929866530666230307113055
Abstract: Meclofenoxate (centrophenoxine) is a nootropic drug that has shown beneficial therapeutic effects in several neuronal disorders including Alzheimer's disease, senile dementia, tardive dyskinesia, and cerebral ischemia. Administration of meclofenoxate led to increased dopamine levels and…
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Keywords:
aggregation;
meclofenoxate inhibits;
synuclein vitro;
inhibits aggregation ... See more keywords