Norepinephrine Inhibits Alzheimer's Amyloid-β Peptide Aggregation and Destabilizes Amyloid-β Protofibrils: A Molecular Dynamics Simulation Study.
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DOI: 10.1021/acschemneuro.8b00537
Abstract: The abnormal self-assembly of amyloid-β (Aβ) peptides into toxic fibrillar aggregates is associated with the pathogenesis of Alzheimer's disease (AD). The inhibition of β-sheet-rich oligomer formation is considered as the primary therapeutic strategy for AD.… read more here.
Keywords: norepinephrine inhibits; aggregation; inhibits alzheimer; amyloid peptide ... See more keywords