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Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26351
Abstract: APOE is the strongest genetic factor for late‐onset Alzheimer's disease (AD). A specific conformation of the ApoE protein is present in amyloid‐β (Aβ) containing plaques. Immunotherapy targeting ApoE in plaques reduces brain Aβ deposits in…
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Keywords:
inhibits associated;
antibody inhibits;
apoe antibody;
tau seeding ... See more keywords