(−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters
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DOI: 10.1021/acsomega.0c05586
Abstract: Organic anion transporter 1 (OAT1, SLC22A6) and 3 (OAT3, SLC22A8) are multispecific drug transporters highly expressed on the basolateral membranes of the renal proximal tubules. OAT1 and OAT3 mediate the tubular secretion of clinically significant… read more here.
Keywords: oat1 oat3; epigallocatechin gallate; organic anion; inhibits human ... See more keywords
Acipimox inhibits human carbonic anhydrases
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DOI: 10.1080/14756366.2022.2037579
Abstract: Abstract Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1)… read more here.
Keywords: human carbonic; acipimox inhibits; carbonic anhydrases; chemistry ... See more keywords
Corrigendum: Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.792330
Abstract: [This corrects the article DOI: 10.3389/fphar.2021.628621.]. read more here.
Keywords: human gallbladder; corrigendum isorhamnetin; isorhamnetin inhibits; inhibits human ... See more keywords
Canagliflozin Inhibits Human Endothelial Cell Inflammation through the Induction of Heme Oxygenase-1
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DOI: 10.3390/ijms23158777
Abstract: Sodium-glucose co-transporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM). Studies have also shown that canagliflozin directly acts on endothelial cells (ECs). Since heme oxygenase-1 (HO-1) is an established… read more here.
Keywords: canagliflozin; heme oxygenase; canagliflozin inhibits; inhibits human ... See more keywords
IL-35 inhibits human osteoclastogenesis from monocytes induced by receptor-activator of NF-κB ligand
Sign Up to like & getrecommendations! Published in 2018 at "Central-European Journal of Immunology"
DOI: 10.5114/ceji.2018.77384
Abstract: IL-35 is known as a regulatory cytokine produced by regulatory T cells. It has also been reported that IL-35 suppresses the proliferation of Th17 cells, which is involved in the pathogenesis of many autoimmune diseases.… read more here.
Keywords: induced receptor; osteoclastogenesis monocytes; monocytes induced; human osteoclastogenesis ... See more keywords