NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8+ T cell responses
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102548
Abstract: Summary The recognition of fungi by intracellular NOD-like receptors (NLRs) induces inflammasome assembly and activation. Although the NLRC4 inflammasome has been extensively studied in bacterial infections, its role during fungal infections is unclear. Paracoccidioidomycosis (PCM)… read more here.
Keywords: cell responses; cd8; inhibits nlrp3; nlrp3 inflammasome ... See more keywords
Brevilin A inhibits NLRP3 inflammasome activation in vivo and in vitro by acting on the upstream of NLRP3-induced ASC oligomerization.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.03.025
Abstract: Brevilin A (BA), is a natural biologically active ingredient derived from Centipeda minima with several reports of anti-cancer, while its anti-inflammatory activity is rarely reported. Current studies have found the dysregulated activation of NLRP3 inflammasome… read more here.
Keywords: inflammasome activation; nlrp3 induced; inhibits nlrp3; activation ... See more keywords
Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115582
Abstract: NLRP3 inflammasome is involved in several chronic inflammatory diseases. The inflammatory effect of the NLRP3 inflammasome is executed through IL-1β and IL-18. Therefore, IL-1β is one of the primary targets in chronic inflammatory conditions. However,… read more here.
Keywords: inflammasome activation; asc oligomerization; inhibits nlrp3; safranal inhibits ... See more keywords
Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac028
Abstract: The Nod-like receptor family pyrin domain containing 3 (NLRP3) is a cytosolic innate immune receptor that senses organelle dysfunction induced by various stimuli, such as infectious, environmental, metabolic, and drug stresses. Upon activation, NLRP3 forms… read more here.
Keywords: activation preventing; dysfunction; inflammasome activation; inhibits nlrp3 ... See more keywords
Estradiol inhibits NLRP3 inflammasome in fibroblast‐like synoviocytes activated by lipopolysaccharide and adenosine triphosphate
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.13198
Abstract: Nucleotide binding domain and leucine‐rich repeat pyrin 3 domain (NLRP3) inflammasome is known for activating pro‐inflammatory cytokines in knee osteoarthritis (OA). This study was performed to identify whether NLRP3 inflammasome can be triggered by lipopolysaccharides… read more here.
Keywords: fibroblast like; like synoviocytes; inflammasome fibroblast; inhibits nlrp3 ... See more keywords
Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01920
Abstract: The NLRP3 inflammasome is a multiprotein complex that plays a key role in the innate immune system, and aberrant activation of this complex is involved in the pathogenesis of inflammatory diseases. Carvedilol (CVL) is an… read more here.
Keywords: inducer inhibits; novel autophagy; cvl; inhibits nlrp3 ... See more keywords