A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model.
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DOI: 10.1165/rcmb.2020-0452oc
Abstract: Orai1 is a plasma membrane Ca2+ channel that mediates store operated Ca2+ entry (SOCE) and regulates inflammation. Short palate lung and nasal epithelial clone 1 (SPLUNC1) is an asthma gene modifier which inhibits Orai1/SOCE via… read more here.
Keywords: asthma model; inhibits orai1; microscopy; inflammation murine ... See more keywords