TG02 inhibits proteasome inhibitor-induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma.
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DOI: 10.1182/bloodadvances.2017006122
Abstract: Proteasome inhibition activates multiple kinases in myeloma cells resulting in the phosphorylation of p53, HSP27, c-JUN, and HSF1.TG02 inhibits proteasome inhibitor (PI)-induced HSF1 pS326, representing a novel mechanism for a TG02 and PI combination. read more here.
Keywords: inhibits proteasome; proteasome inhibitor; inhibitor induced; tg02 inhibits ... See more keywords