FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.067
Abstract: SUMMARY Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant accumulation of collagen-secreting myofibroblasts. Development of effective therapies is limited due to incomplete understanding of molecular mechanisms regulating myofibroblast expansion. FOXF1 transcription factor is expressed in… read more here.
Keywords: foxf1 inhibits; inhibits pulmonary; fibrosis; cdh11 ... See more keywords
Pentoxifylline Inhibits Pulmonary Fibrosis by Regulating Cellular Senescence in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.848263
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease, and its occurrence and development are mediated by cellular senescence. Drugs targeting senescent cells seem like a promising and efficacious strategy for IPF treatment. Previous studies… read more here.
Keywords: inhibits pulmonary; pulmonary fibrosis; senescence; cellular senescence ... See more keywords