Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells
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DOI: 10.1038/s41375-019-0470-4
Abstract: IL-6 signaling plays a crucial role in the pathogenesis of a number of diseases, including multiple myeloma, primary amyloidosis, cytokine release syndrome and other inflammatory conditions. It is central for the growth and survival of… read more here.
Keywords: signaling decreasing; inhibits signaling; metformin inhibits; multiple myeloma ... See more keywords
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
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DOI: 10.1038/s41467-017-00864-2
Abstract: IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its… read more here.
Keywords: inhibits signaling; aptamer specifically; structure; dna aptamer ... See more keywords