Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17207
Abstract: Eg5 is a kinesin spindle protein that controls chromosomal segregation in mitosis and is thus a critical drug target for cancer therapy. We report the discovery of a potent, selective inhibitor of Eg5 designated YL001.… read more here.
Keywords: cancer; inhibits tumor; yl001; eg5 inhibitor ... See more keywords
CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.928498
Abstract: The suppressive function of T-regulatory cells (Tregs) can have a detrimental effect on immune responses against tumor cells. Within the Treg cells subset, a new non-classical population has been reported, which expresses high levels of… read more here.
Keywords: tr1 cells; tumor; tumor growth; inhibits tumor ... See more keywords
miR-497 inhibits tumor growth and migration of osteosarcoma by targeting plexinA4 and CDK6.
Sign Up to like & getrecommendations! Published in 2020 at "Neoplasma"
DOI: 10.4149/neo_2020_200108n26
Abstract: MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level which have been reported to be involved in the pathogenesis of various cancers. In the present study, we found that miR-497 was… read more here.
Keywords: inhibits tumor; mir 497; plexina4 cdk6; 497 inhibits ... See more keywords