KSHV vPK inhibits Wnt signaling via preventing interactions between β-catenin and TCF4.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.089
Abstract: Viral factors interact with host cellular proteins, leading to dysregulation of signaling pathways. The Wnt pathway is known to participate in embryonic development and oncogenesis under dysregulation conditions. A downstream factor of the Wnt signaling… read more here.
Keywords: inhibits wnt; wnt signaling; catenin tcf4; signaling pathway ... See more keywords
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemical biology"
DOI: 10.1038/nchembio.2510
Abstract: Wnt (wingless)/β-catenin signaling is critical for tumor progression and is frequently activated in colorectal cancer as a result of the mutation of adenomatous polyposis coli (APC); however, therapeutic agents targeting this pathway for clinical use… read more here.
Keywords: inhibits wnt; catenin citrullination; wnt signaling; catenin ... See more keywords