The antifibrinolytic and anti-inflammatory effects of a high initial-dose tranexamic acid in total knee arthroplasty: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "International Orthopaedics"
DOI: 10.1007/s00264-019-04469-w
Abstract: Purpose The aim of this study was to evaluate the effects of a high initial-dose (60 mg/kg) intravenous tranexamic acid (IV-TXA) on fibrinolysis and inflammation after total knee arthroplasty (TKA). Methods A total of 132 patients… read more here.
Keywords: initial dose; effects high; tranexamic acid; total knee ... See more keywords
Comment on the article “The antifibrinolytic and anti-inflammatory effects of a high initial-dose tranexamic acid in total knee arthroplasty: a randomized controlled trial”
Sign Up to like & getrecommendations! Published in 2020 at "International Orthopaedics"
DOI: 10.1007/s00264-020-04554-5
Abstract: To the Editor, I have read with great interest the article by Lei et al.—it has been an edifying experience to come across such a clinically relevant and important research where the authors have sought… read more here.
Keywords: initial dose; tranexamic acid; total knee; high initial ... See more keywords
How to select the initial dose for a pediatric study?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2022.2149770
Abstract: In typical clinical development programs, a new drug is first developed for the adult use. Drugs are often approved for adult use or in the process of obtaining approval in adults in the target indication… read more here.
Keywords: select initial; development; dose pediatric; initial dose ... See more keywords
Determining the optimal initial dose for Japanese patients with nocturnal polyuria using an initial dose of desmopressin 50 μg
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DOI: 10.1111/luts.12474
Abstract: There is no consistent opinion on the optimal initial dose of desmopressin for patients with nocturnal polyuria. Over a period of 12 weeks, we investigated the safety and efficacy of an initial dose of 50 μg of… read more here.
Keywords: patients nocturnal; optimal initial; initial dose; nocturnal polyuria ... See more keywords
Initial dose of oncolytic myxoma virus programs durable antitumor immunity independent of in vivo viral replication
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DOI: 10.1136/jitc-2020-000804
Abstract: Background Oncolytic therapy uses live-replicating viruses to improve the immunological status of treated tumors. Critically, while these viruses are known to self-amplify in vivo, clinical oncolytic therapies still appear to display a strong dose dependence… read more here.
Keywords: initial dose; oncolytic myxoma; myxoma virus; treated tumors ... See more keywords
Clinical effectiveness of apatinib at different doses in patients with advanced gastric cancer as the third-line or further treatment: Results from a post-marketing phase IV study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e16037
Abstract: e16037 Background: Apatinib, a highly selective VEGFR2 inhibitor, has shown a clinical benefit as third-line or further-line treatment in patients with gastric cancer in a randomized phase III study with the initial dose of 850mg.… read more here.
Keywords: treatment; gastric cancer; line; phase ... See more keywords
Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation
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DOI: 10.3389/fphar.2021.717932
Abstract: Many factors have been described to contribute to voriconazole (VCZ) interpatient variability in plasma concentrations, especially CYP2C19 genetic variability. In 2014, Hicks et al. presented data describing the correlation between VCZ plasma concentrations and CYP2C19… read more here.
Keywords: initial dose; target concentrations; preemptive genotyping; vcz ... See more keywords