Articles with "initial segment" as a keyword



Photo from wikipedia

The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

Sign Up to like & get
recommendations!
Published in 2017 at "Developmental Psychobiology"

DOI: 10.1002/dev.21453

Abstract: Plasticity of the axon initial segment (AIS) is a newly discovered type of structural plasticity that regulates cell excitability. AIS plasticity has been reported to happen during normal development of neocortex and also in a… read more here.

Keywords: initial segment; plasticity axon; axon initial; ais ... See more keywords
Photo by mybbor from unsplash

Glucose increases the length and spacing of the lattice structure of the axon initial segment

Sign Up to like & get
recommendations!
Published in 2022 at "Microscopy Research and Technique"

DOI: 10.1002/jemt.24122

Abstract: The axon initial segment (AIS) plays an important role in maintaining neuronal polarity and initiating action potentials (APs). The AIS adapts to its environment by changing its length and distance from the cell body, resulting… read more here.

Keywords: structure; microscopy; lattice structure; ais plasticity ... See more keywords
Photo from wikipedia

Modifications of the axon initial segment during the hibernation of the Syrian hamster

Sign Up to like & get
recommendations!
Published in 2018 at "Brain Structure and Function"

DOI: 10.1007/s00429-018-1753-7

Abstract: Mammalian hibernation is a natural process in which the brain undergoes profound adaptive changes that appear to protect the brain from extreme hypoxia and hypothermia. In addition to a virtual cessation of neural and metabolic… read more here.

Keywords: initial segment; axon initial; hibernation; hibernation syrian ... See more keywords
Photo from wikipedia

Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure.

Sign Up to like & get
recommendations!
Published in 2021 at "Molecular neurobiology"

DOI: 10.1007/s12035-021-02531-6

Abstract: The axon initial segment (AIS) is essential for maintaining neuronal polarity, modulating protein transport into the axon, and action potential generation. These functions are supported by a distinctive actin and microtubule cytoskeleton that controls axonal… read more here.

Keywords: initial segment; axon initial; ais; density ... See more keywords
Photo from archive.org

A constitutively-active IKK-complex at the axon initial segment

Sign Up to like & get
recommendations!
Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2017.10.020

Abstract: BACKGROUND Previous studies provided evidence for an accumulation of IκB-kinase (IKK) α/β at the axon initial segment (AIS), a neuronal compartment defined by ankyrin-G expression. Here we explored whether the presence of the IKK-complex at… read more here.

Keywords: initial segment; axon initial; constitutively active; ikk ... See more keywords
Photo by charlesdeluvio from unsplash

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.

Sign Up to like & get
recommendations!
Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.02.060

Abstract: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiological function… read more here.

Keywords: initial segment; axon initial; tmem106b; ftld risk ... See more keywords
Photo from wikipedia

Length impairments of the axon initial segment in rodent models of attention-deficit hyperactivity disorder and autism spectrum disorder

Sign Up to like & get
recommendations!
Published in 2022 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2021.105273

Abstract: The axon initial segment (AIS) is a structural neuronal compartment of the proximal axon that plays key roles in sodium channel clustering, action potential initiation, and signal propagation of neuronal outputs. Mutations in constitutive genes… read more here.

Keywords: ais length; disorder; initial segment; neurodevelopmental disorders ... See more keywords
Photo by susan_wilkinson from unsplash

The axon initial segment as a source of neuropathic pain

Sign Up to like & get
recommendations!
Published in 2022 at "Brain"

DOI: 10.1093/brain/awac156

Abstract: This scientific commentary refers to ‘Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain’ by Nascimento et al. (https://doi.org/10.1093/brain/awac078). read more here.

Keywords: initial segment; neuropathic pain; axon initial; segment source ... See more keywords
Photo from wikipedia

Quantitative analysis of the GABAergic innervation of the soma and axon initial segment of pyramidal cells in the human and mouse neocortex.

Sign Up to like & get
recommendations!
Published in 2022 at "Cerebral cortex"

DOI: 10.1093/cercor/bhac314

Abstract: Perisomatic GABAergic innervation in the cerebral cortex is carried out mostly by basket and chandelier cells, which differentially participate in the control of pyramidal cell action potential output and synchronization. These cells establish multiple synapses… read more here.

Keywords: initial segment; gabaergic innervation; axon initial; human mouse ... See more keywords
Photo by 20164rhodi from unsplash

ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks.

Sign Up to like & get
recommendations!
Published in 2023 at "Human molecular genetics"

DOI: 10.1093/hmg/ddad081

Abstract: PURPOSE To characterize a novel neurodevelopmental syndrome due to loss-of-function (LoF) variants in Ankyrin 2 (ANK2), and to explore the effects on neuronal network dynamics and homeostatic plasticity in human induced pluripotent stem cell-derived neurons.… read more here.

Keywords: network; loss function; plasticity; activity ... See more keywords
Photo by magnusdiv from unsplash

Axon initial segment plasticity accompanies enhanced excitation of visual cortical neurons in aged rats

Sign Up to like & get
recommendations!
Published in 2018 at "Neuroreport"

DOI: 10.1097/wnr.0000000000001145

Abstract: Recent studies have indicated that the structure of the axon initial segment (AIS) of neurons is highly plastic in response to changes in neuronal activity. Whether an age-related enhancement of neuronal responses in the visual… read more here.

Keywords: aged rats; initial segment; neurons aged; axon initial ... See more keywords