Initial steps of the dopamine story
Sign Up to like & getrecommendations! Published in 2017 at "Revue Neurologique"
DOI: 10.1016/j.neurol.2017.10.011
Abstract: At the end of 1959, it was while preparing a review on monoamine oxidase inhibitors (MAOIs) at the Faculty of Pharmacy, that I discovered the early development of modern neuropharmacology, which started around 1955. Surprised… read more here.
Keywords: initial steps; dopamine story; steps dopamine; striatum ... See more keywords
Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor: Insights from Equilibrium and Nonequilibrium Simulations.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.04.008
Abstract: Nicotinic acetylcholine receptors (nAChRs) modulate synaptic transmission in the nervous system. These receptors have emerged as therapeutic targets in drug discovery for treating several conditions, including Alzheimer's disease, pain, and nicotine addiction. In this in… read more here.
Keywords: equilibrium nonequilibrium; initial steps; identification initial; steps signal ... See more keywords
Binding and Flip as Initial Steps for BP-100 Antimicrobial Actions
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45075-5
Abstract: BP100 is a short antimicrobial peptide and can also act as a molecule-carrier into cells. Like with other antimicrobial peptides, the precise mechanism of membrane disruption is not fully understood. Here we use computer simulations… read more here.
Keywords: initial steps; negatively charged; flip initial; steps 100 ... See more keywords
Zooming in on the initial steps of catalytic NO reduction using metal clusters
Sign Up to like & getrecommendations! Published in 2022 at "Physical Chemistry Chemical Physics"
DOI: 10.1039/d1cp05760j
Abstract: The study of reactions relevant to heterogeneous catalysis on the surface of well-defined metal clusters with full control over the number of consituent atoms and elemental composition can lead to a detailed insight into the… read more here.
Keywords: metal clusters; steps catalytic; initial steps; catalytic reduction ... See more keywords
Initial Steps to Engineer Coproheme Decarboxylase to Obtain Stereospecific Monovinyl, Monopropionyl Deuterohemes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.807678
Abstract: The oxidative decarboxylation of coproheme to form heme b by coproheme decarboxylase is a stereospecific two-step reaction. In the first step, the propionate at position two (p2) is cleaved off the pyrrole ring A to… read more here.
Keywords: engineer coproheme; decarboxylase; initial steps; propionate position ... See more keywords
Initial Steps in Mammalian Autophagosome Biogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00146
Abstract: During the last decade, autophagy has been pointed out as a central process in cellular homeostasis with the consequent implication in most cellular settings and human diseases pathology. At present, there is significant data available… read more here.
Keywords: initial steps; autophagosome biogenesis; mammalian autophagosome; steps mammalian ... See more keywords
The Beginning of the End: Initial Steps in the Degradation of Plasma Membrane Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.00680
Abstract: The plasma membrane (PM), as border between the inside and the outside of a cell, is densely packed with proteins involved in the sensing and transmission of internal and external stimuli, as well as transport… read more here.
Keywords: initial steps; degradation; membrane proteins; steps degradation ... See more keywords