Allosteric Probe Recognition Initiated Cascade Transcription Amplification for Sensitive Analysis of Exosomes
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DOI: 10.1002/cbic.202200067
Abstract: Sensitive and accurate analysis of exosomes is important for many biological processes including as a biomarker for cerebral venous thrombosis (CVT) diagnosis and therapy. Herein, we established a sensitive and specific exosome detection approach based… read more here.
Keywords: recognition; recognition initiated; analysis exosomes; amplification ... See more keywords
Target-Initiated Cascade Signal Amplification Lights up a G-Quadruplex for a Label-Free Detection of Circular Ribonucleic Acids.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01901
Abstract: Circular ribonucleic acids (circRNAs) are a type of RNA that originates through back-splicing events from linear primary transcripts. CircRNAs display high structural resistance and tissue specificity. Accurate quantification of the circRNA expression level is of… read more here.
Keywords: label free; target initiated; ribonucleic acids; initiated cascade ... See more keywords
One-step construction of molecular complexity by tert-butyl nitrite (TBN)-initiated cascade α,β-sp3 C-H bond difunctionalization and C-N bond cleavage.
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DOI: 10.1039/c8cc06946h
Abstract: TBN-initiated cascade multifunctionalization of inert C-H and C-N bonds in N-arylazacycles has been realized under transition-metal free conditions, in which the synthetically useful oxime, N-NO and aldehyde functional groups were constructed in only one synthetic… read more here.
Keywords: bond; tbn initiated; one step; initiated cascade ... See more keywords
A facile access to 1-substituted and unsubstituted 3-isoquinolinones via Mannich or Sn2 initiated cascade reactions under catalyst-free conditions
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DOI: 10.1039/d3ra00378g
Abstract: Herein we report new cascade processes for the easy access to 1-substituted and C-unsubstituted 3-isoquinolinones. The Mannich initiated cascade reaction led to the synthesis of novel 1-substituted 3-isoquinolinones under catalyst-free conditions in the presence of… read more here.
Keywords: free conditions; access substituted; catalyst free; initiated cascade ... See more keywords