Targeting CXCR4 to suppress glioma‐initiating cells and chemoresistance in glioma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11836
Abstract: Glioma initiating cells (GICs), also known as glioma stem cells, display the capacity to recapitulate the functional diversity within the tumor. Despite the great progress achieved over the last decades, defining the key molecular regulators… read more here.
Keywords: cxcr4; klf5; glioma initiating; glioma ... See more keywords
Wnt/IL‐1β/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32419
Abstract: Malignant pleural mesothelioma (MPM) is a tumor with high chemoresistance and poor prognosis. MPM‐initiating cells (ICs) are known to be drug resistant, but it is unknown if and how stemness‐related pathways determine chemoresistance. Moreover, there… read more here.
Keywords: mpm; chemoresistance; mesothelioma; abcb5 ... See more keywords
Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2909
Abstract: Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor that is refractory to existing therapeutic regimens, which reflects the presence of stem‐like cells, termed glioma‐initiating cells (GICs). The complex interactions between different signaling… read more here.
Keywords: brg1; chromatin remodeling; stemness chemosensitivity; initiating cells ... See more keywords
Demystifying the Differences Between Tumor-Initiating Cells and Cancer Stem Cells in Colon Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Current Colorectal Cancer Reports"
DOI: 10.1007/s11888-018-0421-x
Abstract: Purpose of ReviewTumor-initiating cells and cancer stem cells refer to a subpopulation of self-renewing cells involved in tumor initiation and tumor maintenance, respectively. With this review, we aimed to define the functional and molecular differences… read more here.
Keywords: cancer stem; initiating cells; cancer; stem ... See more keywords
Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.09.007
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Glioblastoma multiforme (GBM) is the most frequent and aggressive type of brain tumor due, at least in part, to its poor response to current anticancer treatments. These features… read more here.
Keywords: cbd; initiating cells; glioma initiating; tmz ... See more keywords
The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models.
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2019.04.015
Abstract: The Ataxia Telangiectasia Mutated (ATM)-mediated DNA damage response (DDR) is a major mechanism of resistance of glioblastoma (GB) - initiating cells (GICs) to radiotherapy. The closely related Ataxia Telangiectasia and Rad3-related protein (ATR) is also… read more here.
Keywords: toxicity; tumor; initiating cells; inhibition ... See more keywords
microRNA-29a regulates liver tumor-initiating cells expansion via Bcl-2 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111781
Abstract: MicroRNAs (miRNAs) participate in tumorigenesis, progression, recurrence and drug resistance of hepatocellular carcinoma (HCC). However, few miRNAs have been identified and entered clinical practice. Herein, we report that miR-29a is downregulated in tumor-initiating cells (T-ICs)… read more here.
Keywords: mir 29a; expansion; tumor initiating; initiating cells ... See more keywords
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09309-4
Abstract: In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bivalent state, having both activating H3K4me3 and repressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3. Whether… read more here.
Keywords: initiating cells; self renewal; differentiation; indian hedgehog ... See more keywords
Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy
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DOI: 10.1080/08820139.2017.1280051
Abstract: ABSTRACT Cancer-initiating cells (CICs) represent a relatively rare subpopulation of cells endowed with self-renewal, stemness properties, tumorigenicity in immunodeficient mice, and resistance to standard therapies as well as to immunotherapy. Here, we review the biological… read more here.
Keywords: immunoresistance properties; initiating cells; antigen; cancer initiating ... See more keywords
Identification and Characterization of Tumor-Initiating Cells in Multiple Myeloma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djz159
Abstract: BACKGROUND Treatment failures in cancers, including multiple myeloma (MM) are most likely due to the persistence of a minor population of tumor initiating cells (TICs), which are non-cycling or slowly-cycling and very drug-resistant. METHODS Gene… read more here.
Keywords: cd24 cells; tumor initiating; initiating cells; multiple myeloma ... See more keywords
STEM-06. TISSUE FACTOR SIGNALING IN GLIOBLASTOMA TUMOR-INITIATING CELLS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.980
Abstract: Glioblastoma (GBM) is an aggressive form of brain cancer with few treatment options, characterized by over-activation of receptor tyrosine kinases (RTKs). Brain tumor-initiating cells (BTICs) is a subpopulation of cells in GBM which have the… read more here.
Keywords: tumor initiating; initiating cells; tissue factor; stem tissue ... See more keywords