FCHO controls AP2’s initiating role in endocytosis through a PtdIns(4,5)P2-dependent switch
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DOI: 10.1126/sciadv.abn2018
Abstract: Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 requires membrane-localized Fer/Cip4 homology domain-only proteins (FCHO). Here, live-cell enhanced… read more here.
Keywords: fcho controls; controls ap2; initiating role; endocytosis ... See more keywords