CDKAL1 Drives the Maintenance of Cancer Stem‐Like Cells by Assembling the eIF4F Translation Initiation Complex
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DOI: 10.1002/advs.202206542
Abstract: Cancer stem‐like cells (CSCs) have a unique translation mode, but little is understood about the process of elongation, especially the contribution of tRNA modifications to the maintenance of CSCs properties. Here, it is reported that,… read more here.
Keywords: cdkal1; eif4f translation; initiation complex; translation initiation ... See more keywords
Core Mediator structure at 3.4 Å extends model of transcription initiation complex
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DOI: 10.1038/nature22328
Abstract: Mediator is a multiprotein co-activator that binds the transcription pre-initiation complex (PIC) and regulates RNA polymerase (Pol) II. The Mediator head and middle modules form the essential core Mediator (cMed), whereas the tail and kinase… read more here.
Keywords: transcription; mediator; initiation complex; structure ... See more keywords
Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways
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DOI: 10.1093/nar/gkw1251
Abstract: Abstract In bacteria, the start site and the reading frame of the messenger RNA are selected by the small ribosomal subunit (30S) when the start codon, typically an AUG, is decoded in the P-site by… read more here.
Keywords: initiation; structure 30s; 30s pre; initiation complex ... See more keywords
Structure of a human 48S translational initiation complex
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DOI: 10.1126/science.aba4904
Abstract: Finding the start Eukaryotic translation involves many players in a dynamic and well-orchestrated process. A 43S preinitiation complex (PIC) comprises the 40S ribosomal subunit; initiation factors, including the eIF3 complex, which is known to play… read more here.
Keywords: initiation; microscopy; initiation complex; human 48s ... See more keywords
Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA
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DOI: 10.7554/elife.22520
Abstract: RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish that RbpA and CarD cooperatively stimulate formation of an intermediate (RP2) leading to RPo; formation of RP2… read more here.
Keywords: transcription; mycobacterial transcription; initiation complex; rbpa ... See more keywords