Comprehensive analysis of biological networks and the eukaryotic initiation factor 4A-3 gene as pivotal in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29596
Abstract: Eukaryotic initiation factor 4A-3 (EIF4A3) is a core component of the exon junction complex (EJC). Abnormalities in EIF4A3 are associated with carcinogenesis. The present study aimed to determine the biological role of EIF4A3 in hepatocellular… read more here.
Keywords: hepatocellular carcinoma; eukaryotic initiation; analysis; initiation factor ... See more keywords
Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03663-z
Abstract: Cellular signals that influence Cap-dependent translation have assumed significant relevance in the backdrop of their enforced dysregulation during oncogenesis. Eukaryotic initiation factor 4E(eIF4E), the mRNA cap-binding protein, has emerged as a key player to facilitate… read more here.
Keywords: initiation factor; phosphorylation; eukaryotic initiation; cap dependent ... See more keywords
The role of eukaryotic translation initiation factor 5A-1 (eIF5A-1) gene in HPV 16 E6 induces cell growth in human cervical squamous carcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.018
Abstract: Human Papillomavirus (HPV) is considered as the major risk factor for the development and progression of cervical cancer. The high expression of HPV 16 E6 may be the causative factor for induction and maintenance of… read more here.
Keywords: carcinoma; initiation factor; hpv; factor ... See more keywords
Upregulation of eukaryotic translation initiation factor 3 subunit a promotes cell survival in ameloblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2019.02.016
Abstract: OBJECTIVES This study aimed to detect the expression of eukaryotic translation initiation factor 3 subunit a (eIF3a) in ameloblastoma (AB) tissues compared with normal oral mucosa (NOM) tissues and investigate the roles of eIF3a in… read more here.
Keywords: eukaryotic translation; ameloblastoma; translation initiation; factor subunit ... See more keywords
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01225
Abstract: The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we describe the discovery of a… read more here.
Keywords: factor tfiid; transcription initiation; initiation factor; tfiid subunit ... See more keywords
Eukaryotic initiation factor 2 signaling behind neural invasion linked with lymphatic and vascular invasion in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00727-3
Abstract: Perineural invasion (PNI) is a typical poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC). The mechanisms linking PNI to poor prognosis remain unclear. This study aimed to clarify what changes occurred alongside PNI in PDAC.… read more here.
Keywords: eukaryotic initiation; pdac; invasion; initiation factor ... See more keywords
Therapeutic targeting of eukaryotic initiation factor (eIF) 4E.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220285
Abstract: Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow information… read more here.
Keywords: factor eif; therapeutic targeting; eukaryotic initiation; initiation factor ... See more keywords
Clinical significance of eukaryotic translation initiation factor 5A2 in papillary thyroid cancer
Sign Up to like & getrecommendations! Published in 2020 at "Bioengineered"
DOI: 10.1080/21655979.2020.1848753
Abstract: ABSTRACT Eukaryotic translation initiation factor 5A2 (eIF5A2) plays an important role in tumor progression and prognosis evaluation. However, the potential role of eIF5A2 in human papillary thyroid cancer (PTC) is unknown. In this study, we… read more here.
Keywords: eif5a2; factor 5a2; initiation factor; ptc ... See more keywords
eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjaa018
Abstract: Abstract Studies over the past three years have substantially expanded the involvements of eukaryotic initiation factor 3 (eIF3) in messenger RNA (mRNA) translation. It now appears that this multi-subunit complex is involved in every possible… read more here.
Keywords: eif3 protein; translation; protein synthesis; initiation factor ... See more keywords
Eukaryotic initiation factor 4F promotes a reorientation of eukaryotic initiation factor 3 binding on the 5′ and the 3′ UTRs of barley yellow dwarf virus mRNA
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac284
Abstract: Abstract Viral mRNAs that lack a 5′ m7GTP cap and a 3′ poly-A tail rely on structural elements in their untranslated regions (UTRs) to form unique RNA-protein complexes that regulate viral translation. Recent studies of… read more here.
Keywords: initiation factor; factor; eukaryotic initiation; bydv ... See more keywords
Eukaryotic initiation factor 6 modulates the metamorphosis and reproduction of Tribolium castaneum
Sign Up to like & getrecommendations! Published in 2022 at "Insect Molecular Biology"
DOI: 10.1111/imb.12817
Abstract: Eukaryotic initiation factor 6 (eIF6) is necessary for ribosome biogenesis and translation, but eIF6 has been poorly elucidated in insects. Phylogenetic analysis demonstrated that eIF6 originated from one ancestral gene among animals and exhibited specific… read more here.
Keywords: metamorphosis reproduction; initiation factor; expression; castaneum ... See more keywords