Identification of eukaryotic translation initiation factors and the temperature-dependent nature of Turnip mosaic virus epidemics in allopolyploid Brassica juncea
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DOI: 10.1007/s13205-020-2058-0
Abstract: Eukaryotic translation initiation factors (eIFs) are essential protein complexes involved in the translation of mRNA into proteins. These initiation factors are generally used as targets in the control of plant RNA virus infections. In the… read more here.
Keywords: juncea; temperature dependent; translation; initiation factors ... See more keywords
Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors
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DOI: 10.1016/j.molcel.2020.09.021
Abstract: Summary Cellular responses to environmental stress are frequently mediated by RNA-binding proteins (RBPs). Here, we examined global RBP dynamics in Saccharomyces cerevisiae in response to glucose starvation and heat shock. Each stress induced rapid remodeling… read more here.
Keywords: induced translation; initiation; stress induced; translation ... See more keywords
Distinct pre-initiation steps in human mitochondrial translation
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DOI: 10.1038/s41467-020-16503-2
Abstract: Translation initiation in human mitochondria relies upon specialized mitoribosomes and initiation factors, mtIF2 and mtIF3, which have diverged from their bacterial counterparts. Here we report two distinct mitochondrial pre-initiation assembly steps involving those factors. Single-particle… read more here.
Keywords: initiation; mitochondria; translation; initiation factors ... See more keywords
SARS-CoV-2 Nsp1 cooperates with initiation factors EIF1 and 1A to selectively enhance translation of viral RNA
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DOI: 10.1371/journal.ppat.1011535
Abstract: A better mechanistic understanding of virus-host dependencies can help reveal vulnerabilities and identify opportunities for therapeutic intervention. Of particular interest are essential interactions that enable production of viral proteins, as those could target an early… read more here.
Keywords: sars cov; factors eif1; nsp1 cooperates; translation ... See more keywords
Eukaryotic initiation factors: central factor associating mRNA translational plasticity during neuropathic pain progression
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DOI: 10.3389/fneur.2025.1566205
Abstract: Neuropathic pain causes plasticity in the nervous system, which is often associated with altered protein synthesis. Proteins are the key executors of cellular functions, and their alteration is closely related to the occurrence of neuropathic… read more here.
Keywords: pain; initiation factors; mrna translational; neuropathic pain ... See more keywords